| pubmed-article:8635998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8635998 | lifeskim:mentions | umls-concept:C0242275 | lld:lifeskim |
| pubmed-article:8635998 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:8635998 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8635998 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:8635998 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8635998 | pubmed:dateCreated | 1996-7-9 | lld:pubmed |
| pubmed-article:8635998 | pubmed:abstractText | The c-cbl gene was cloned as the cellular homolog of the v-cbl oncogene that is the transforming component of a murine tumorigenic retrovirus, CAS NS-1, though the biological roles of c-Cbl remain to be elucidated. We have previously reported that c-Cbl is implicated in the signal transduction triggered by granulocyte-macrophage colony-stimulating factor or erythropoietin in hematopoietic cells. Here, we observed tyrosine phosphorylation of C-cbl in cells expressing epidermal growth factor receptor depending on EGF stimulation and in v-src transformed cells. Furthermore, c-Cbl was revealed to associate with v-Src in vivo. By means of binding experiments using glutathione S-transferase fusion proteins, we have found that the SH2 and SH3 domains of many proteins bind to c-Cbl. These findings strongly suggest that c-Cbl is implicated in a wide variety of signal transduction pathways, including those of EGF receptor and Src protein, as well as in the signaling pathways of hematopoietic cells. | lld:pubmed |
| pubmed-article:8635998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8635998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8635998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8635998 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8635998 | pubmed:issn | 0910-5050 | lld:pubmed |
| pubmed-article:8635998 | pubmed:author | pubmed-author:SasakiKK | lld:pubmed |
| pubmed-article:8635998 | pubmed:author | pubmed-author:HiraiHH | lld:pubmed |
| pubmed-article:8635998 | pubmed:author | pubmed-author:TanakaTT | lld:pubmed |
| pubmed-article:8635998 | pubmed:author | pubmed-author:YazakiYY | lld:pubmed |
| pubmed-article:8635998 | pubmed:author | pubmed-author:UenoHH | lld:pubmed |
| pubmed-article:8635998 | pubmed:author | pubmed-author:MiyagawaKK | lld:pubmed |
| pubmed-article:8635998 | pubmed:author | pubmed-author:MitaniKK | lld:pubmed |
| pubmed-article:8635998 | pubmed:author | pubmed-author:HanazonoYY | lld:pubmed |
| pubmed-article:8635998 | pubmed:author | pubmed-author:OdaiHH | lld:pubmed |
| pubmed-article:8635998 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8635998 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:8635998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8635998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8635998 | pubmed:pagination | 1119-26 | lld:pubmed |
| pubmed-article:8635998 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8635998 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8635998 | pubmed:articleTitle | c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts. | lld:pubmed |
| pubmed-article:8635998 | pubmed:affiliation | Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo. | lld:pubmed |
| pubmed-article:8635998 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8635998 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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