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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1996-7-9
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pubmed:abstractText |
The c-cbl gene was cloned as the cellular homolog of the v-cbl oncogene that is the transforming component of a murine tumorigenic retrovirus, CAS NS-1, though the biological roles of c-Cbl remain to be elucidated. We have previously reported that c-Cbl is implicated in the signal transduction triggered by granulocyte-macrophage colony-stimulating factor or erythropoietin in hematopoietic cells. Here, we observed tyrosine phosphorylation of C-cbl in cells expressing epidermal growth factor receptor depending on EGF stimulation and in v-src transformed cells. Furthermore, c-Cbl was revealed to associate with v-Src in vivo. By means of binding experiments using glutathione S-transferase fusion proteins, we have found that the SH2 and SH3 domains of many proteins bind to c-Cbl. These findings strongly suggest that c-Cbl is implicated in a wide variety of signal transduction pathways, including those of EGF receptor and Src protein, as well as in the signaling pathways of hematopoietic cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/CBL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cbl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GRB2 Adaptor Protein,
http://linkedlifedata.com/resource/pubmed/chemical/GRB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Grb2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Protein pp60(v-src),
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-cbl,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0910-5050
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1119-26
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8635998-3T3 Cells,
pubmed-meshheading:8635998-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:8635998-Animals,
pubmed-meshheading:8635998-Cell Line, Transformed,
pubmed-meshheading:8635998-Epidermal Growth Factor,
pubmed-meshheading:8635998-Fibroblasts,
pubmed-meshheading:8635998-GRB2 Adaptor Protein,
pubmed-meshheading:8635998-Humans,
pubmed-meshheading:8635998-Leukemia,
pubmed-meshheading:8635998-Mice,
pubmed-meshheading:8635998-Oncogene Protein pp60(v-src),
pubmed-meshheading:8635998-Phosphorylation,
pubmed-meshheading:8635998-Protein Processing, Post-Translational,
pubmed-meshheading:8635998-Proteins,
pubmed-meshheading:8635998-Proto-Oncogene Proteins,
pubmed-meshheading:8635998-Proto-Oncogene Proteins c-cbl,
pubmed-meshheading:8635998-Receptor, Epidermal Growth Factor,
pubmed-meshheading:8635998-Signal Transduction,
pubmed-meshheading:8635998-Tumor Cells, Cultured,
pubmed-meshheading:8635998-Tyrosine,
pubmed-meshheading:8635998-Ubiquitin-Protein Ligases,
pubmed-meshheading:8635998-src Homology Domains
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pubmed:year |
1995
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pubmed:articleTitle |
c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts.
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pubmed:affiliation |
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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