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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1996-7-1
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pubmed:abstractText |
Mutations in the endothelin 3 (EDN3) gene severely affect the development of neural crest-derived melanocytes. In this paper, we report the action of EDN3 on neural crest cells in vitro. The presence of EDN3 leads to a large increase in the number of cells, the majority of which eventually differentiate into melanocytes that aggregate to form a reproducible pigmentation pattern. Quantitative analysis of the effect of different culture conditions revealed that EDN3 initially promotes neural crest cell proliferation. This phase of expansion, which can be prolonged for a few weeks if the cells are replaced regularly, is followed by both a decrease in cell proliferation and the onset of melanocytic differentiation. Therefore, EDN3 is a potent mitogen for early neural crest cell precursors that can give rise to melanocytes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-1376287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-14138974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-1769335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-2068114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-2455901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-7534243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-7544170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-7686497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-7689991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-8001159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-8001160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-8041763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-8129941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-8198607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-8261134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-8325247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-8330517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-8365563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-8405679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8632985-849800
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3892-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8632985-Animals,
pubmed-meshheading:8632985-Cell Differentiation,
pubmed-meshheading:8632985-Cell Division,
pubmed-meshheading:8632985-Cells, Cultured,
pubmed-meshheading:8632985-Chick Embryo,
pubmed-meshheading:8632985-Culture Media,
pubmed-meshheading:8632985-Culture Techniques,
pubmed-meshheading:8632985-Drug Interactions,
pubmed-meshheading:8632985-Endothelins,
pubmed-meshheading:8632985-Kinetics,
pubmed-meshheading:8632985-Melanocytes,
pubmed-meshheading:8632985-Neural Crest,
pubmed-meshheading:8632985-Quail,
pubmed-meshheading:8632985-Recombinant Proteins,
pubmed-meshheading:8632985-Stem Cell Factor,
pubmed-meshheading:8632985-Time Factors,
pubmed-meshheading:8632985-Tissue Extracts
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pubmed:year |
1996
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pubmed:articleTitle |
Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture.
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pubmed:affiliation |
Institut d'Embryologie Cellulaire et Moléculaire du Centre National de la Recherche Scientifique, Nogent-sur-Marne, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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