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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1996-6-28
|
| pubmed:abstractText |
It is widely accepted that cerebral acetylcholine is necessary for learning and memory, but little is known about the type of muscarinic receptors involved in these functions. To investigate this problem, [3H]-N-methyl-scopolamine which binds to different types of muscarinic receptors, [3H]-Pirenzepine an M1 receptor antagonist, and [3H]-Oxotremorine-M which binds mainly to M2 receptors, were used as ligands to look for possible changes in muscarinic receptor density in neostriatum (NEO), hippocampus (HIP), amygdala (AMY), and temporo-parietal neocortex (CTX), after testing for retention of inhibitory avoidance, trained with high or low footshock intensities. After low reinforcement there was an M1 postsynaptic receptor up-regulation in NEO, HIP, and CTX, and an M2 presynaptic receptor down-regulation in HIP, which suggests a concerted pre- and postsynaptic cholinergic activation in this area. An up-regulation of both M1 and M2 receptors was detected in CTX of low and high footshocked animals, which indicates the presence of a cortical postsynaptic M2 receptor.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylscopolamine,
http://linkedlifedata.com/resource/pubmed/chemical/Oxotremorine,
http://linkedlifedata.com/resource/pubmed/chemical/Pirenzepine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic,
http://linkedlifedata.com/resource/pubmed/chemical/Scopolamine Derivatives
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0024-3205
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
58
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
799-809
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8632727-Amygdala,
pubmed-meshheading:8632727-Animals,
pubmed-meshheading:8632727-Avoidance Learning,
pubmed-meshheading:8632727-Brain,
pubmed-meshheading:8632727-Cerebral Cortex,
pubmed-meshheading:8632727-Discrimination (Psychology),
pubmed-meshheading:8632727-Hippocampus,
pubmed-meshheading:8632727-Kinetics,
pubmed-meshheading:8632727-Male,
pubmed-meshheading:8632727-Memory,
pubmed-meshheading:8632727-N-Methylscopolamine,
pubmed-meshheading:8632727-Neostriatum,
pubmed-meshheading:8632727-Organ Specificity,
pubmed-meshheading:8632727-Oxotremorine,
pubmed-meshheading:8632727-Pirenzepine,
pubmed-meshheading:8632727-Rats,
pubmed-meshheading:8632727-Rats, Wistar,
pubmed-meshheading:8632727-Receptors, Muscarinic,
pubmed-meshheading:8632727-Reinforcement (Psychology),
pubmed-meshheading:8632727-Scopolamine Derivatives
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Changes in rat brain muscarinic receptors after inhibitory avoidance learning.
|
| pubmed:affiliation |
Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV, IPN, México.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|