Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-7-2
pubmed:abstractText
The association of viral infections with autoimmune central nervous system (CNS) diseases such as post-infectious encephalomyelitis and possibly multiple sclerosis (MS) prompted the investigation to understand how virus infection could modulate autoimmune responses. Recombinant vaccinia viruses encoding an encephalitogenic portion of myelin basic protein (MBP) were evaluated in an animal model for human demyelinating disease, experimental allergic encephalomyelitis (EAE). We have determined that mice vaccinated with recombinant viruses encoding an encephalitogenic region of MBP were protected from EAE. In vivo depletion of CD8+ T cells did not abrogate this protection, suggesting lack of regulation by this cell type. These studies demonstrate that virus infection may be a means to modulated immune responsiveness to CNS disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
163-73
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:8632058-Amino Acid Sequence, pubmed-meshheading:8632058-Animals, pubmed-meshheading:8632058-Antibody Formation, pubmed-meshheading:8632058-Antigens, CD8, pubmed-meshheading:8632058-Autoimmune Diseases, pubmed-meshheading:8632058-Cells, Cultured, pubmed-meshheading:8632058-Disease Models, Animal, pubmed-meshheading:8632058-Encephalomyelitis, Autoimmune, Experimental, pubmed-meshheading:8632058-Epitopes, pubmed-meshheading:8632058-Female, pubmed-meshheading:8632058-Humans, pubmed-meshheading:8632058-Hypersensitivity, Delayed, pubmed-meshheading:8632058-Male, pubmed-meshheading:8632058-Mice, pubmed-meshheading:8632058-Mice, Inbred Strains, pubmed-meshheading:8632058-Molecular Sequence Data, pubmed-meshheading:8632058-Myelin Basic Proteins, pubmed-meshheading:8632058-Peptide Fragments, pubmed-meshheading:8632058-Recombination, Genetic, pubmed-meshheading:8632058-Species Specificity, pubmed-meshheading:8632058-T-Lymphocytes, pubmed-meshheading:8632058-Vaccination, pubmed-meshheading:8632058-Vaccinia virus
pubmed:year
1996
pubmed:articleTitle
Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis.
pubmed:affiliation
Department of Neurology, University of Utah, Salt Lake City 84132, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't