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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1996-7-2
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pubmed:abstractText |
The IE2 gene of human cytomegalovirus has been implicated in the development of coronary restenosis, and the gene product appears to inhibit p53-dependent transactivation. Here we describe an analysis of the IE2-p53 interaction. Repression of p53 function by IE2 requires two separable domains of IE2. The N terminus of IE2 interacts with p53. IE2 has little effect on the ability of p53 to bind specific DNA sequences. Reduction of the transactivation activity of p53 is caused by a transcriptional repression function contributed by the C-terminal domain of IE2. These findings suggest that IE2 may function as a transcriptional repressor, which is recruited to p53's target genes by interacting with p53.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GAL4 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/IE2 protein, Cytomegalovirus,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/UL115 protein, Human herpesvirus 5,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein H, Cytomegalovirus,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein H, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein O, cytomegalovirus
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
271
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3534-40
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8631958-Binding Sites,
pubmed-meshheading:8631958-Cell Line,
pubmed-meshheading:8631958-Cytomegalovirus,
pubmed-meshheading:8631958-DNA-Binding Proteins,
pubmed-meshheading:8631958-Fungal Proteins,
pubmed-meshheading:8631958-Glutathione Transferase,
pubmed-meshheading:8631958-Humans,
pubmed-meshheading:8631958-Immediate-Early Proteins,
pubmed-meshheading:8631958-Membrane Glycoproteins,
pubmed-meshheading:8631958-Plasmids,
pubmed-meshheading:8631958-Protein Biosynthesis,
pubmed-meshheading:8631958-Recombinant Fusion Proteins,
pubmed-meshheading:8631958-Recombinant Proteins,
pubmed-meshheading:8631958-Restriction Mapping,
pubmed-meshheading:8631958-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:8631958-Trans-Activators,
pubmed-meshheading:8631958-Transcription, Genetic,
pubmed-meshheading:8631958-Transcription Factors,
pubmed-meshheading:8631958-Transfection,
pubmed-meshheading:8631958-Tumor Suppressor Protein p53,
pubmed-meshheading:8631958-Viral Envelope Proteins,
pubmed-meshheading:8631958-Viral Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Human cytomegalovirus immediate-early protein IE2 tethers a transcriptional repression domain to p53.
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pubmed:affiliation |
Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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