Linked Life Data

8630571

Source:http://linkedlifedata.com/resource/pubmed/id/8630571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-7-1
pubmed:abstractText
In order to test the hypothesis that changes in lung function induced by ozone (O3) are correlated with cellular and biochemical indices of respiratory tract injury/inflammation, we exposed 20 healthy subjects, on separate days, to O3 (0.2 ppm) and filtered air for 4 h during exercise. Symptom questionnaires were administered before and after exposure, and pulmonary function tests (FEV1, FVC, and SRaw) were performed before, during, and immediately after each exposure. Fiberoptic bronchoscopy, with isolated left main bronchus proximal airway lavage (PAL) and bronchoalveolar lavage (BAL; bronchial fraction, the first 10 ml of fluid recovered) of the right middle lobe, was performed 18 h after each exposure. The PAL, bronchial fraction, and BAL fluids were analyzed for the following end points: total and differential cell counts, and total protein, fibronectin, interleukin-8 (IL-8), and granulocyte-macrophage colony-stimulating factor (GM-CSF) concentrations. The study population was divided into two groups, least-sensitive (n = 12; mean O3-induced change in FEV1 = -7.0%) and most-sensitive (n = 8; mean O3-induced change in FEV1 = -36.0%). We found a significant O3 effect on SRaw (p<0.001) and lower respiratory symptoms (p<0.001) for all subjects combined, but no significant differences between the least- and most-sensitive groups. Ozone exposure increased significantly percent neutrophils in PAL (p=0.01); percent neutrophils, total protein, and IL-8 in bronchial fraction (p<0.001, p<0.001, and p<0.01, respectively); and percent neutrophils, total protein, fibronectin, and GM-CSF in BAL (p<0.001, p<0.001, p<0.01, p=0.05, respectively) for all subjects combined; there were no significant differences, however, between least- and most-sensitive groups. Our results indicate that levels of O3-induced symptoms and respiratory tract injury/inflammation were not correlated with the magnitude of decrements in FEV1 and FVC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1073-449X
pubmed:author
pubmed:issnType
Print
pubmed:volume
153
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
904-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:8630571-Adult, pubmed-meshheading:8630571-Airway Resistance, pubmed-meshheading:8630571-Biopsy, pubmed-meshheading:8630571-Bronchitis, pubmed-meshheading:8630571-Bronchoalveolar Lavage Fluid, pubmed-meshheading:8630571-Bronchoscopy, pubmed-meshheading:8630571-Cell Count, pubmed-meshheading:8630571-Female, pubmed-meshheading:8630571-Fiber Optic Technology, pubmed-meshheading:8630571-Fibronectins, pubmed-meshheading:8630571-Forced Expiratory Volume, pubmed-meshheading:8630571-Granulocyte-Macrophage Colony-Stimulating Factor, pubmed-meshheading:8630571-Humans, pubmed-meshheading:8630571-Interleukin-8, pubmed-meshheading:8630571-Leukocyte Count, pubmed-meshheading:8630571-Male, pubmed-meshheading:8630571-Neutrophils, pubmed-meshheading:8630571-Ozone, pubmed-meshheading:8630571-Physical Exertion, pubmed-meshheading:8630571-Proteins, pubmed-meshheading:8630571-Vital Capacity
pubmed:year
1996
pubmed:articleTitle
Ozone-induced decrements in FEV1 and FVC do not correlate with measures of inflammation.
pubmed:affiliation
Center for Occupational and Environmental Health, Cardiovascular Research Institute, University of California, San Francisco 94143-0854, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't