Linked Life Data

8630239

Source:http://linkedlifedata.com/resource/pubmed/id/8630239

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-7-2
pubmed:databankReference
pubmed:abstractText
We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2. Coexpression of SUR2 and the inward rectifier K+ channel subunit Kir6.2 in COS1 cells reconstitutes the properties of K(ATP) channels described in cardiac and skeletal muscle. The SUR2/Kir6.2 channel is less sensitive than the SUR/Kir6.2 channel (the pancreatic beta cell KATP channel) to both ATP and the sulfonylurea glibenclamide and is activated by the cardiac K(ATP) channel openers, cromakalim and pinacidil, but not by diazoxide. In addition, SUR2 binds glibenclamide with lower affinity. The present study shows that the ATP sensitivity and pharmacological properties of K(ATP) channels are determined by a family of structurally related but functionally distinct sulfonylurea receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1011-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8630239-ATP-Binding Cassette Transporters, pubmed-meshheading:8630239-Adenosine Triphosphate, pubmed-meshheading:8630239-Amino Acid Sequence, pubmed-meshheading:8630239-Animals, pubmed-meshheading:8630239-Cloning, Molecular, pubmed-meshheading:8630239-Gene Expression, pubmed-meshheading:8630239-Molecular Sequence Data, pubmed-meshheading:8630239-Potassium Channels, pubmed-meshheading:8630239-Potassium Channels, Inwardly Rectifying, pubmed-meshheading:8630239-RNA, Messenger, pubmed-meshheading:8630239-Rats, pubmed-meshheading:8630239-Receptors, Drug, pubmed-meshheading:8630239-Recombinant Proteins, pubmed-meshheading:8630239-Sequence Alignment, pubmed-meshheading:8630239-Sequence Homology, Amino Acid, pubmed-meshheading:8630239-Signal Transduction, pubmed-meshheading:8630239-Tissue Distribution
pubmed:year
1996
pubmed:articleTitle
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.
pubmed:affiliation
Division of Molecular Medicine Center for Biomedical Science, Chiba University School of Medicine, Chuo-ku, Chiba 260, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't