| pubmed-article:8628998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8628998 | lifeskim:mentions | umls-concept:C0034678 | lld:lifeskim |
| pubmed-article:8628998 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:8628998 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:8628998 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:8628998 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8628998 | pubmed:issue | 5250 | lld:pubmed |
| pubmed-article:8628998 | pubmed:dateCreated | 1996-6-25 | lld:pubmed |
| pubmed-article:8628998 | pubmed:abstractText | The RAS guanine nucleotide binding proteins activate multiple signaling events that regulate cell growth and differentiation. In quiescent fibroblasts, ectopic expression of activated H-RAS (H-RASV12, where V12 indicates valine-12) induces membrane ruffling, mitogen-activated protein (MAP) kinase activation, and stimulation of DNA synthesis. A mutant of activated H-RAS, H-RASV12C40 (where C40 indicates cysteine-40), was identified that was defective for MAP kinase activation and stimulation of DNA synthesis, but retained the ability to induce membrane ruffling. Another mutant of activated H-RAS, H-RASV12S35 (where S35 indicates serine-35), which activates MAP kinase, was defective for stimulation of membrane ruffling and induction of DNA synthesis. Expression of both mutants resulted in a stimulation of DNA synthesis that was comparable to that induced by H-RASV12. These results indicate that membrane ruffling and activation of MAP kinase represent distinct RAS effector pathways and that input from both pathways is required for the mitogenic activity of RAS. | lld:pubmed |
| pubmed-article:8628998 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8628998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8628998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8628998 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8628998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8628998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8628998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8628998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8628998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8628998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8628998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8628998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8628998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8628998 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8628998 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:8628998 | pubmed:author | pubmed-author:WhiteM AMA | lld:pubmed |
| pubmed-article:8628998 | pubmed:author | pubmed-author:WiglerM HMH | lld:pubmed |
| pubmed-article:8628998 | pubmed:author | pubmed-author:Bar-SagiDD | lld:pubmed |
| pubmed-article:8628998 | pubmed:author | pubmed-author:JonesonTT | lld:pubmed |
| pubmed-article:8628998 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8628998 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:8628998 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8628998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8628998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8628998 | pubmed:pagination | 810-2 | lld:pubmed |
| pubmed-article:8628998 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:meshHeading | pubmed-meshheading:8628998-... | lld:pubmed |
| pubmed-article:8628998 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8628998 | pubmed:articleTitle | Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. | lld:pubmed |
| pubmed-article:8628998 | pubmed:affiliation | Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook 11794, USA. | lld:pubmed |
| pubmed-article:8628998 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8628998 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8628998 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8628998 | lld:pubmed |
