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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1996-6-21
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pubmed:abstractText |
The interrelationship between cytotoxin-associated gene A (CagA), vacuolating cytotoxin (VacA), and Helicobacter pylori-related diseases was investigated in 155 H. pylori-infected patients. Four (7%) of 60 subjects had mixed cagA+ and cagA- H. pylori infections. The H. pylori isolates from 98.3% of 121 patients with anti-CagA antibodies were cagA+. The occurrence of cagA+ H. pylori among 76 patients with peptic ulcer disease (PUD) was higher (93.4%) than among 79 patients with functional dyspepsia (FD; 64.6%) (odds ratio [OR] = 7.80; P < .001). VacA+ isolates were isolated from 56.6% of the PUD patients and 35.4% of the FD patients (OR = 2.37; P = .0132). For type I (cagA+VacA+) isolates, these numbers were 56.6% and 31.6%, respectively (P = .003). Only 4% of the 71 VacA+ isolates were cagA-. In addition, 37% of the patients with PUD were infected with cagA+VacA- H. pylori. Chi 2 results did not improve when VacA was entered into the model in the presence of cagA, indicating that only cagA is associated with PUD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1171-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8627069-Adult,
pubmed-meshheading:8627069-Antibodies, Bacterial,
pubmed-meshheading:8627069-Antigens, Bacterial,
pubmed-meshheading:8627069-Bacterial Proteins,
pubmed-meshheading:8627069-Base Sequence,
pubmed-meshheading:8627069-Cell Line,
pubmed-meshheading:8627069-Cohort Studies,
pubmed-meshheading:8627069-Cytotoxins,
pubmed-meshheading:8627069-Dyspepsia,
pubmed-meshheading:8627069-Epithelial Cells,
pubmed-meshheading:8627069-Gastric Mucosa,
pubmed-meshheading:8627069-Genes, Bacterial,
pubmed-meshheading:8627069-Helicobacter Infections,
pubmed-meshheading:8627069-Helicobacter pylori,
pubmed-meshheading:8627069-Humans,
pubmed-meshheading:8627069-Molecular Sequence Data,
pubmed-meshheading:8627069-Peptic Ulcer,
pubmed-meshheading:8627069-Polymerase Chain Reaction,
pubmed-meshheading:8627069-Vacuoles
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pubmed:year |
1996
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pubmed:articleTitle |
The interrelationship between cytotoxin-associated gene A, vacuolating cytotoxin, and Helicobacter pylori-related diseases.
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pubmed:affiliation |
University of Amsterdam, Department of Medical Microbiology, Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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