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pubmed-article:8627055pubmed:abstractTextThe mechanisms of inhibition of cytomegalovirus (CMV) infection by human CD13 (aminopeptidase N)-specific antibodies were studied. These antibodies protect CD13-negative and -positive cells from CMV infection only if incubated with the virus inoculum, suggesting they bind to CMV virions. The association of a CD13-like molecule with virions was further supported by the transfer of CD13 immunoreactivity to the surface of CD13-negative cells upon binding of CMV; the binding of CD13-specific antibodies directly to the surface of CMV virions; and the presence of anti-CD13 immunoreactive bands, including one with mobility similar to that of native cellular CD13 on immunoblots of proteins of purified CMV particles. Importantly, CD13-specific antibodies neutralize CMV in urine of neonates with congenital CMV, indicating that the CD13-like molecule is associated with natural CMV and not acquired in vitro. These studies demonstrate that a CD13-like molecule is associated with CMV particles and may be important in CMV pathogenesis.lld:pubmed
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pubmed-article:8627055pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8627055pubmed:articleTitleNeutralization of human cytomegalovirus by human CD13-specific antibodies.lld:pubmed
pubmed-article:8627055pubmed:affiliationDivision of Pediatrics, City of Hope National Medical Center, Duarte, California 91010-0269, USA.lld:pubmed
pubmed-article:8627055pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8627055pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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