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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1996-6-21
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pubmed:abstractText |
The mechanisms of inhibition of cytomegalovirus (CMV) infection by human CD13 (aminopeptidase N)-specific antibodies were studied. These antibodies protect CD13-negative and -positive cells from CMV infection only if incubated with the virus inoculum, suggesting they bind to CMV virions. The association of a CD13-like molecule with virions was further supported by the transfer of CD13 immunoreactivity to the surface of CD13-negative cells upon binding of CMV; the binding of CD13-specific antibodies directly to the surface of CMV virions; and the presence of anti-CD13 immunoreactive bands, including one with mobility similar to that of native cellular CD13 on immunoblots of proteins of purified CMV particles. Importantly, CD13-specific antibodies neutralize CMV in urine of neonates with congenital CMV, indicating that the CD13-like molecule is associated with natural CMV and not acquired in vitro. These studies demonstrate that a CD13-like molecule is associated with CMV particles and may be important in CMV pathogenesis.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
173
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1062-71
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8627055-Animals,
pubmed-meshheading:8627055-Antibodies, Monoclonal,
pubmed-meshheading:8627055-Antibodies, Viral,
pubmed-meshheading:8627055-Antibody Specificity,
pubmed-meshheading:8627055-Antigens, CD13,
pubmed-meshheading:8627055-Cell Line,
pubmed-meshheading:8627055-Cross Reactions,
pubmed-meshheading:8627055-Cytomegalovirus,
pubmed-meshheading:8627055-Cytomegalovirus Infections,
pubmed-meshheading:8627055-Epitopes,
pubmed-meshheading:8627055-Female,
pubmed-meshheading:8627055-Humans,
pubmed-meshheading:8627055-Infant, Newborn,
pubmed-meshheading:8627055-Mice,
pubmed-meshheading:8627055-Neutralization Tests,
pubmed-meshheading:8627055-Virion
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pubmed:year |
1996
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pubmed:articleTitle |
Neutralization of human cytomegalovirus by human CD13-specific antibodies.
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pubmed:affiliation |
Division of Pediatrics, City of Hope National Medical Center, Duarte, California 91010-0269, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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