| pubmed-article:8626717 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8626717 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:8626717 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:8626717 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:8626717 | lifeskim:mentions | umls-concept:C0282549 | lld:lifeskim |
| pubmed-article:8626717 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:8626717 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:8626717 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:8626717 | pubmed:dateCreated | 1996-6-27 | lld:pubmed |
| pubmed-article:8626717 | pubmed:abstractText | The human promyelocytic leukemia cell line HL-60 can be induced to differentiate toward neutrophils and subsequently die via apoptosis in vitro. In this paper, we investigated the roles of protein-tyrosine kinases (PTKs) in retinoic acid (RA)-induced granulocytic differentiation of HL-60 cells. Accompanying the RA-induced differentiation, activities of src family PTKs Lyn and Fgr became detected and reached a plateau 2 days after the stimulation. The immunoblotting using anti-phosphotyrosine antibody (PY-20) showed that the proteins of 56 and 53 kDa were predominantly tyrosine-phosphorylated at day 2. Adsorption and immunoprecipitation of the cell lysate by specific antibodies evidenced that these phosphotyrosine-containing proteins are Lyn and Fgr PTKs. The degree of both activities and tyrosine phosphorylation of these PTKs was reduced to be minimal at day 5 when the HL-60 cells start to die by apoptosis. The inhibitors of PTKs, herbimycin A and genistein, were demonstrated to cause premature cell death of HL-60 cells in the presence of RA. The death was the consequence of an apoptotic process. The Ra-treated HL-60 cells, when incubated with specific c-lyn or c-fgr antisense oligodeoxynucleotide, also underwent premature death at day 2. These data implicate that Lyn and Fgr PTKs prevent programmed cell death to promote granulocytic differentiation of HL-60 cells. | lld:pubmed |
| pubmed-article:8626717 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8626717 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8626717 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8626717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8626717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8626717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8626717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8626717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8626717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8626717 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8626717 | pubmed:month | May | lld:pubmed |
| pubmed-article:8626717 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8626717 | pubmed:author | pubmed-author:YamamotoTT | lld:pubmed |
| pubmed-article:8626717 | pubmed:author | pubmed-author:KatagiriTT | lld:pubmed |
| pubmed-article:8626717 | pubmed:author | pubmed-author:OmuraSS | lld:pubmed |
| pubmed-article:8626717 | pubmed:author | pubmed-author:KatagiriKK | lld:pubmed |
| pubmed-article:8626717 | pubmed:author | pubmed-author:IrieSS | lld:pubmed |
| pubmed-article:8626717 | pubmed:author | pubmed-author:YokoyamaK KKK | lld:pubmed |
| pubmed-article:8626717 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8626717 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:8626717 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8626717 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8626717 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8626717 | pubmed:pagination | 11557-62 | lld:pubmed |
| pubmed-article:8626717 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:8626717 | pubmed:meshHeading | pubmed-meshheading:8626717-... | lld:pubmed |
| pubmed-article:8626717 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8626717 | pubmed:articleTitle | Lyn and Fgr protein-tyrosine kinases prevent apoptosis during retinoic acid-induced granulocytic differentiation of HL-60 cells. | lld:pubmed |
| pubmed-article:8626717 | pubmed:affiliation | Institute of Biomatrix, Nippi Inc., Tokyo, Japan. | lld:pubmed |
| pubmed-article:8626717 | pubmed:publicationType | Journal Article | lld:pubmed |
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