| pubmed-article:8626617 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8626617 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8626617 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:8626617 | lifeskim:mentions | umls-concept:C0017755 | lld:lifeskim |
| pubmed-article:8626617 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:8626617 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8626617 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8626617 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8626617 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:8626617 | pubmed:dateCreated | 1996-6-21 | lld:pubmed |
| pubmed-article:8626617 | pubmed:abstractText | Overproduction of glucose by the liver is the major cause of fasting hyperglycemia in both insulin-dependent and non-insulin-dependent diabetes mellitus. The distal enzymatic step in the process of glucose output is catalyzed by the glucose-6-phosphatase complex. We show here that 90% partially pancreatectomized diabetic rats have a >5-fold increase in the messenger RNA and a 3-4-fold increase in the protein level of the catalytic subunit of glucose-6-phosphatase in the liver. Normalization of the plasma glucose concentration in diabetic rats with either insulin or the glycosuric agent phlorizin normalized the hepatic glucose-6-phosphatase messenger RNA and protein within approximately 8 h. Conversely, phlorizin failed to decrease hepatic glucose-6-phosphatase gene expression in diabetic rats when the fall in the plasma glucose concentration was prevented by glucose infusion. These data indicate that in vivo gene expression of glucose-6-phosphatase in the diabetic liver is regulated by glucose independently from insulin, and thus prolonged hyperglycemia may result in overproduction of glucose via increased expression of this protein. | lld:pubmed |
| pubmed-article:8626617 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8626617 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8626617 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8626617 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8626617 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8626617 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8626617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8626617 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8626617 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8626617 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8626617 | pubmed:author | pubmed-author:ChenWW | lld:pubmed |
| pubmed-article:8626617 | pubmed:author | pubmed-author:ElyJ HJH | lld:pubmed |
| pubmed-article:8626617 | pubmed:author | pubmed-author:BarzilaiNN | lld:pubmed |
| pubmed-article:8626617 | pubmed:author | pubmed-author:RossettiLL | lld:pubmed |
| pubmed-article:8626617 | pubmed:author | pubmed-author:MassillonDD | lld:pubmed |
| pubmed-article:8626617 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8626617 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:8626617 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8626617 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8626617 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8626617 | pubmed:pagination | 9871-4 | lld:pubmed |
| pubmed-article:8626617 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8626617 | pubmed:meshHeading | pubmed-meshheading:8626617-... | lld:pubmed |
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| pubmed-article:8626617 | pubmed:meshHeading | pubmed-meshheading:8626617-... | lld:pubmed |
| pubmed-article:8626617 | pubmed:meshHeading | pubmed-meshheading:8626617-... | lld:pubmed |
| pubmed-article:8626617 | pubmed:meshHeading | pubmed-meshheading:8626617-... | lld:pubmed |
| pubmed-article:8626617 | pubmed:meshHeading | pubmed-meshheading:8626617-... | lld:pubmed |
| pubmed-article:8626617 | pubmed:meshHeading | pubmed-meshheading:8626617-... | lld:pubmed |
| pubmed-article:8626617 | pubmed:meshHeading | pubmed-meshheading:8626617-... | lld:pubmed |
| pubmed-article:8626617 | pubmed:meshHeading | pubmed-meshheading:8626617-... | lld:pubmed |
| pubmed-article:8626617 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8626617 | pubmed:articleTitle | Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats. | lld:pubmed |
| pubmed-article:8626617 | pubmed:affiliation | Diabetes Research and Training Center and Division of Endocrinology, Albert Einstein College of Medicine, Bronx, New York 10461, USA. | lld:pubmed |
| pubmed-article:8626617 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8626617 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8626617 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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