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rdf:type |
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lifeskim:mentions |
umls-concept:C0031153,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C0205307,
umls-concept:C0439603,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600,
umls-concept:C2700400
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pubmed:issue |
4
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pubmed:dateCreated |
1996-6-24
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pubmed:abstractText |
The majority of peritoneal T lymphocytes have been shown to be CD8+ and to co-express CDw60. Expression of CDw60 characterizes CD8 T cells capable of secreting interleukin (IL)-4 and supporting IgG production by B cells. We analyzed at the clonal level the functional cytokine profile of CD8+ T lymphocytes from the normal human peritoneum. While the majority of the clones produced interferon (IFN)-gamma and exhibited high alloantigen-specific cytolytic activity, some clones secreted IL-4 and IL-5 but no detectable IFN-gamma. These Th2-type CD8+ T cell clones provided substantial B cell help for IgG and IgA synthesis and exhibited reduced cytolytic activity. Our results suggest that distinct subsets of CD8+ T cell may occur in different immune compartments.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CDw60 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
957-60
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8625996-Antigens, CD,
pubmed-meshheading:8625996-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:8625996-B-Lymphocytes,
pubmed-meshheading:8625996-CD8-Positive T-Lymphocytes,
pubmed-meshheading:8625996-Cell Separation,
pubmed-meshheading:8625996-Cytotoxicity, Immunologic,
pubmed-meshheading:8625996-Female,
pubmed-meshheading:8625996-Gene Expression,
pubmed-meshheading:8625996-Humans,
pubmed-meshheading:8625996-Immunoglobulin A,
pubmed-meshheading:8625996-Immunoglobulin G,
pubmed-meshheading:8625996-Interferon-gamma,
pubmed-meshheading:8625996-Interleukin-4,
pubmed-meshheading:8625996-Interleukin-5,
pubmed-meshheading:8625996-Lymphocyte Cooperation,
pubmed-meshheading:8625996-Lymphocyte Count,
pubmed-meshheading:8625996-Peritoneum,
pubmed-meshheading:8625996-RNA, Messenger,
pubmed-meshheading:8625996-Th2 Cells
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pubmed:year |
1996
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pubmed:articleTitle |
T lymphocytes from the normal human peritoneum contain high frequencies of Th2-type CD8+ T cells.
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pubmed:affiliation |
Department of Medicine, University of Munich, Germany.
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pubmed:publicationType |
Journal Article
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