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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-6-24
|
| pubmed:abstractText |
In order to investigate the role of pathogenic T cells in RA, the establishment of an RA model using patients' T cells is thought to be essential. In this study, multiple and severe destructive arthritis was established by transferring in vitro-stimulated synovial fluid T (SFT) cells from patients with RA through simultaneous injection into knee joint and peritoneal cavity of SCID mice without causing xenogeneic graft-versus-host disease (GVHD). Neither the transfer of unstimulated SFT cells nor sole i.p. injection was sufficient to induce severe arthritis. Interestingly, in contrast with SFT cells, in vitro-activated peripheral blood lymphocytes from RA patients failed to trigger such arthritis, suggesting that pathogenic T cells might be concentrated in synovial fluid of RA patients. This, the first severe arthritis model mimicking RA induced by RA patients' T cells, is expected to provide important information about RA pathogenesis and a possible therapeutic approach.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0009-9104
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
104
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
247-54
|
| pubmed:dateRevised |
2008-11-20
|
| pubmed:meshHeading |
pubmed-meshheading:8625516-Aged,
pubmed-meshheading:8625516-Animals,
pubmed-meshheading:8625516-Antigens, Surface,
pubmed-meshheading:8625516-Arthritis,
pubmed-meshheading:8625516-Arthritis, Rheumatoid,
pubmed-meshheading:8625516-Disease Models, Animal,
pubmed-meshheading:8625516-Female,
pubmed-meshheading:8625516-Graft vs Host Disease,
pubmed-meshheading:8625516-Humans,
pubmed-meshheading:8625516-Immunohistochemistry,
pubmed-meshheading:8625516-Leukocytes, Mononuclear,
pubmed-meshheading:8625516-Lymphocyte Activation,
pubmed-meshheading:8625516-Lymphocyte Transfusion,
pubmed-meshheading:8625516-Male,
pubmed-meshheading:8625516-Mice,
pubmed-meshheading:8625516-Mice, SCID,
pubmed-meshheading:8625516-Middle Aged,
pubmed-meshheading:8625516-Synovial Fluid,
pubmed-meshheading:8625516-T-Lymphocytes
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Successful induction of severe destructive arthritis by the transfer of in vitro-activated synovial fluid T cells from patients with rheumatoid arthritis (RA) in severe combined immunodeficient (SCID) mice.
|
| pubmed:affiliation |
Department of Immunology, Kumamoto University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|