Linked Life Data

8625395

Source:http://linkedlifedata.com/resource/pubmed/id/8625395

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-6-21
pubmed:abstractText
Immunohistochemistry and cholinesterase histochemistry were used to evaluate the structure and neurotransmitter content of the ganglionated plexuses of the human, canine, and opossum (Monodelphis domestica) gallbladders. In each species, the ganglionated plexus consisted of small (mean approximately 4 neurons/ganglion), irregularly dispersed ganglia that were interconnected by bundles of nerve fibers. The density of ganglia was about ten-fold higher in the opossum than in the human or the dog. Immunostaining for choline acetyltransferase (ChAT) was accomplished in the human, dog, opossum, and the guinea pig where all neurons were found to express ChAT-immunoreactivity. In the human, immunoreactivities for vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) were the most abundant followed by substance P (SP). In the dog, immunoreactivity for galanin (GAL) was the strongest, followed closely by VIP and then by SP. NPY-immunoreactive neurons were not observed in the dog, but immunoreactive nerve fibers were seen in the perivascular plexus. In the opossum, immunoreactivity for GAL was the most intense and abundant followed by SP, which was followed by VIP. NPY-immunoreactivity in the opossum was limited to scarce perivascular nerve fibers. Immunoreactivity for calcitonin-gene-related peptide (CGRP) was not observed in neuronal somata, but CGRP/SP-immunoreactive nerve fibers were a feature of each species studied. These findings, along with previously published work on the guinea pig, indicate that it is likely that all gallbladder neurons are cholinergic, and that VIP, SP, and NPY and/or GAL are commonly expressed in gallbladder neurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0302-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
284
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-302
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Structure and chemical coding of human, canine and opossum gallbladder ganglia.
pubmed:affiliation
Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington 05405, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.