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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-6-27
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pubmed:abstractText |
To study the role of CD40 ligand (CD40L) in the host immune responses against intracellular pathogens, we infected CD40L knockout (CD40L-/-) mice with Leishmania amazonensis. Although wild-type mice were susceptible to infection and developed progressive ulcerative lesions, tissue parasite burdens in CD40L-/- mice were significantly higher. This heightened susceptibility to infection was associated with an impaired T cell and macrophage activation and altered inflammatory response, as reflected by low levels of IFN gamma, lymphotoxin-tumor necrosis factor (LT-TNF), and nitric oxide (NO) production. Furthermore, CD40L-/- mice failed to generate a protective immune response after immunization. These results indicate an essential role of cognate CD40-CD40L interactions in the generation of cellular immune responses against an intracellular parasite.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1074-7613
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-73
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pubmed:dateRevised |
2009-6-30
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pubmed:meshHeading |
pubmed-meshheading:8624816-Animals,
pubmed-meshheading:8624816-Antibodies, Protozoan,
pubmed-meshheading:8624816-Antigens, CD40,
pubmed-meshheading:8624816-Antigens, Protozoan,
pubmed-meshheading:8624816-CD40 Ligand,
pubmed-meshheading:8624816-Disease Susceptibility,
pubmed-meshheading:8624816-Host-Parasite Interactions,
pubmed-meshheading:8624816-Leishmania mexicana,
pubmed-meshheading:8624816-Leishmaniasis, Cutaneous,
pubmed-meshheading:8624816-Ligands,
pubmed-meshheading:8624816-Macrophages, Peritoneal,
pubmed-meshheading:8624816-Membrane Glycoproteins,
pubmed-meshheading:8624816-Mice,
pubmed-meshheading:8624816-Mice, Mutant Strains,
pubmed-meshheading:8624816-Nitric Oxide
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pubmed:year |
1996
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pubmed:articleTitle |
Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection.
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pubmed:affiliation |
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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