Linked Life Data

8624792

Source:http://linkedlifedata.com/resource/pubmed/id/8624792

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-6-25
pubmed:abstractText
The role of AMP and adenosine was investigated in the radiosensitization of normal brain tissues by chlorpromazine. Their metabolism was evaluated by estimating the levels of 5'-nucleotidase and adenosine deaminase activity in the brains of rats treated with chlorpromazine alone or chlorpromazine and irradiation. The extent of lipid peroxidation, measured in terms of the lipid peroxidase enzyme formed, increased with chlorpromazine treatment and irradiation. Chlorpromazine treatment was found to decrease AMP and adenosine metabolism, as shown by a marked reduction in the level of 5'-nucleotidase and ADA activity which was accompanied by a marked curtailment in the DNA, RNA and protein contents of the brain. Chlorpromazine was also found to increase the radiation-induced activity of acid phosphatase, indicating its action on the lysosomal activity of the brain cells. In the present study a low dose of chlorpromazine, i.e. 17 mg/kg body weight, was found to be more effective than a high dose of 34 mg/kg. The results of this study suggest that chlorpromazine probably sensitizes normal brain tissues to radiation by inhibiting AMP and adenosine metabolism via a hydroxy-radical induced decrease in DNA, RNA and protein metabolism with a concomitant increase in lysosomal activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1125-0135
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
290-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Effect of chlorpromazine as a sensitizer of rat brain on radiation-induced AMP and adenosine metabolism.
pubmed:affiliation
School of Sciences, Indira Gandhi National Open University, New Delhi, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't