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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021747,
umls-concept:C0029408,
umls-concept:C0030705,
umls-concept:C0039099,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C1334197,
umls-concept:C1415900,
umls-concept:C1552644,
umls-concept:C1707455,
umls-concept:C1823153,
umls-concept:C2349976,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
1996-6-27
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pubmed:abstractText |
Data concerning the presence of T-cell-derived cytokines in the rheumatic joint are conflicting, challenging the hypothesis that rheumatoid arthritis (RA) is a T-cell-mediated disease. In this study synovial tissue specimens of 11 patients with RA and eight patients with osteoarthritis (OA) were stained for interferon-gamma (IFN-gamma) and its receptor. The level of expression of IFN-gamma was compared with that in tissue specimens of delayed-type hypersensitivity (DTH) reactions of the skin and of chronic tonsillitis. Furthermore, the percentage of T-lymphocytes which stained positive for IFN-gamma was determined using double staining techniques. IFN-gamma and its receptor were detected in all patients with RA and in 7/8 and 3/8, respectively, of patients with OA. Expression of IFN-gamma (P<0.02) and IFN-gamma receptor (P<0.01) in synovial tissue of patients with RA was more abundant compared with that in patients with OA. Although IFN-gamma could be detected in RA synovial tissue, the level of expression was less when compared with DTH reactions of the skin and tonsillitis. The percentage of CD3+ cells being positive for IFN-gamma was approximately 1% in RA, whereas in DTH reactions of the skin it was >90% and in tonsillitis approximately 30%. We conclude that the presence of IFN-gamma and its receptor in RA synovial tissue suggests a role for this cytokine in the ongoing immunological reaction of the inflamed joint.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/interferon gamma receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0263-7103
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
24-32
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8624619-Antigens, CD,
pubmed-meshheading:8624619-Antigens, CD3,
pubmed-meshheading:8624619-Arthritis, Rheumatoid,
pubmed-meshheading:8624619-Female,
pubmed-meshheading:8624619-Humans,
pubmed-meshheading:8624619-Hypersensitivity, Delayed,
pubmed-meshheading:8624619-Interferon-gamma,
pubmed-meshheading:8624619-Male,
pubmed-meshheading:8624619-Osteoarthritis,
pubmed-meshheading:8624619-Receptors, Interferon,
pubmed-meshheading:8624619-Synovial Membrane,
pubmed-meshheading:8624619-Tonsillitis
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pubmed:year |
1996
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pubmed:articleTitle |
Increased expression of interferon (IFN)-gamma together with IFN-gamma receptor in the rheumatoid synovial membrane compared with synovium of patients with osteoarthritis.
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pubmed:affiliation |
Department of Rheumatology, University Hospital Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study
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