| pubmed-article:8624101 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8624101 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:8624101 | lifeskim:mentions | umls-concept:C0392335 | lld:lifeskim |
| pubmed-article:8624101 | lifeskim:mentions | umls-concept:C0297583 | lld:lifeskim |
| pubmed-article:8624101 | pubmed:dateCreated | 1996-6-14 | lld:pubmed |
| pubmed-article:8624101 | pubmed:abstractText | The beta-amyloid precursor protein (beta-APP) has been hypothesized to play an important role in the establishment of synaptic connections. Icv injections of anti-beta APP antibodies into rat brains produced no appreciable effect on subsequent learning of a passive avoidance task whereas memory assessed 1 day later in a retention test was impaired in anti-beta-APP--but not control-IgG-injected animals. This suggests a possible involvement of beta-APPs in cognitive functions. In order to evaluate the properties of the proteolytic A beta-fragment accumulating in Alzheimer's disease brains, four different neuronal cell types were exposed to A beta 1-42 for 24 hours. All cells degenerated in response to A beta, yet chromosomal condensation and internucleosomal DNA fragmentation, typical for apoptosis, occurred in only three of the cell types tested. These findings suggest that beta-APPs may play an important role in cognitive processes and additionally, that their alternative proteolytic product A beta may be differentially toxic to neuronal cell types, inducing cell death either by necrosis or by apoptosis. | lld:pubmed |
| pubmed-article:8624101 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8624101 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8624101 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8624101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8624101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8624101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8624101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8624101 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8624101 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8624101 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:8624101 | pubmed:author | pubmed-author:HuberGG | lld:pubmed |
| pubmed-article:8624101 | pubmed:author | pubmed-author:MorganH SHS | lld:pubmed |
| pubmed-article:8624101 | pubmed:author | pubmed-author:MartinJ RJR | lld:pubmed |
| pubmed-article:8624101 | pubmed:author | pubmed-author:GschwindMM | lld:pubmed |
| pubmed-article:8624101 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8624101 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:8624101 | pubmed:volume | 777 | lld:pubmed |
| pubmed-article:8624101 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8624101 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8624101 | pubmed:pagination | 293-6 | lld:pubmed |
| pubmed-article:8624101 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:meshHeading | pubmed-meshheading:8624101-... | lld:pubmed |
| pubmed-article:8624101 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8624101 | pubmed:articleTitle | beta-APP cognitive function versus beta-amyloid--induced cell death. | lld:pubmed |
| pubmed-article:8624101 | pubmed:affiliation | Pharma Division, Preclinical CNS Research, F. Hoffmann-La Roche Ltd., Basel, Switzerland. | lld:pubmed |
| pubmed-article:8624101 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8624101 | lld:pubmed |
