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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1996-6-14
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pubmed:abstractText |
Our objective was to investigate the effects of recombinant human growth hormone (rhGH) treatment on long-term renal allograft function and histopathology. RhGH is a potent therapy for poor growth after renal transplantation. However, rhGH has proinflammatory properties and may induce acute rejection or accelerate chronic rejection. Nine prepubertal rhGH-treated renal transplanted children and nine pair-matched controls were studied 18 (before the start of rhGH) and 36 months after transplantation (mean duration of rhGH-treatment 14 months). 51Cr-EDTA- and PAH-clearances were performed. A protocol renal biopsy was done at 36 months. Growth showed significant improvement during rhGH (P<0.01). One graft loss occurred in both groups. One acute rejection was seen in the control group. There was no difference in the rate pf change in 51Cr-EDTA-or PAH-clearance between the two groups. Histopathological findings were mostly mild. One new onset chronic rejection developed in both groups. Proximal tubular atrophy was more extensive in the rhGH-treated patients (P<0.05), but there was no uniform trend toward more severe findings. RhGH improved growth, and no significant differences were seen in allograft function or histopathology; however, larger trials controlled for pretreatment renal function and immunosuppression are needed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0041-1337
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
898-903
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8623157-Acute Disease,
pubmed-meshheading:8623157-Child,
pubmed-meshheading:8623157-Child, Preschool,
pubmed-meshheading:8623157-Child Development,
pubmed-meshheading:8623157-Female,
pubmed-meshheading:8623157-Graft Rejection,
pubmed-meshheading:8623157-Graft Survival,
pubmed-meshheading:8623157-Growth,
pubmed-meshheading:8623157-Growth Hormone,
pubmed-meshheading:8623157-Humans,
pubmed-meshheading:8623157-Infant,
pubmed-meshheading:8623157-Kidney,
pubmed-meshheading:8623157-Kidney Transplantation,
pubmed-meshheading:8623157-Male,
pubmed-meshheading:8623157-Recombinant Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Recombinant human growth hormone treatment. Its effect on renal allograft function and histology.
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pubmed:affiliation |
Children's Hospital and Transplantation Laboratory, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article
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