Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1996-6-18
pubmed:databankReference
pubmed:abstractText
Stimulation of the cAMP-dependent signaling pathway exerts an inhibitory effect on the proliferation and effector functions of T cells. The ability of T cells to form high intracellular levels of cAMP is acquired during development in the human thymus and is retained by the majority of mature peripheral T lymphocytes. Here we show that elevated cAMP levels in T cells correlate with the expression of the potent transcriptional repressor ICER (inducible cAMP early repressor) previously described in the hypothalamic-pituitary-gonadal axis. Further, in transcriptional assays in vivo, ICER inhibits calcineurin-mediated expression of the interleukin 2 promoter as well as Tax-mediated transactivation of the human T-lymphotropic virus type I (HTLV-I) promoter. Thus, the induction of ICER in T cells may play an important role in the cAMP-induced quiescence and the persistent latency of HTLV-I.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-1461747, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2243135, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2540166, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2855581, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2933744, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2991048, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2991599, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-3047590, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-3062372, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-411876, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-6205764, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-6364772, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-6977613, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7568187, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7681549, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7693857, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7694367, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7759537, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7904900, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8011294, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8211160, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8252624, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8346196, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8397338, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8397339, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8538746
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3536-41
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:8622971-Amino Acid Sequence, pubmed-meshheading:8622971-Base Sequence, pubmed-meshheading:8622971-Calcineurin, pubmed-meshheading:8622971-Calmodulin-Binding Proteins, pubmed-meshheading:8622971-Cell Differentiation, pubmed-meshheading:8622971-Child, Preschool, pubmed-meshheading:8622971-Conserved Sequence, pubmed-meshheading:8622971-Cyclic AMP, pubmed-meshheading:8622971-Cyclic AMP Response Element Modulator, pubmed-meshheading:8622971-DNA, Complementary, pubmed-meshheading:8622971-DNA Primers, pubmed-meshheading:8622971-DNA-Binding Proteins, pubmed-meshheading:8622971-Genes, pX, pubmed-meshheading:8622971-Human T-lymphotropic virus 1, pubmed-meshheading:8622971-Humans, pubmed-meshheading:8622971-Infant, pubmed-meshheading:8622971-Interleukin-2, pubmed-meshheading:8622971-Molecular Sequence Data, pubmed-meshheading:8622971-Phosphoprotein Phosphatases, pubmed-meshheading:8622971-Promoter Regions, Genetic, pubmed-meshheading:8622971-Repressor Proteins, pubmed-meshheading:8622971-Signal Transduction, pubmed-meshheading:8622971-T-Lymphocytes, pubmed-meshheading:8622971-Transcriptional Activation
pubmed:year
1996
pubmed:articleTitle
cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes.
pubmed:affiliation
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.