rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1996-6-18
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pubmed:databankReference |
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pubmed:abstractText |
Stimulation of the cAMP-dependent signaling pathway exerts an inhibitory effect on the proliferation and effector functions of T cells. The ability of T cells to form high intracellular levels of cAMP is acquired during development in the human thymus and is retained by the majority of mature peripheral T lymphocytes. Here we show that elevated cAMP levels in T cells correlate with the expression of the potent transcriptional repressor ICER (inducible cAMP early repressor) previously described in the hypothalamic-pituitary-gonadal axis. Further, in transcriptional assays in vivo, ICER inhibits calcineurin-mediated expression of the interleukin 2 promoter as well as Tax-mediated transactivation of the human T-lymphotropic virus type I (HTLV-I) promoter. Thus, the induction of ICER in T cells may play an important role in the cAMP-induced quiescence and the persistent latency of HTLV-I.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-1461747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2243135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2540166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2855581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2933744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2991048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-2991599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-3047590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-3062372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-411876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-6205764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-6364772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-6977613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7568187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7681549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7693857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7694367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7759537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-7904900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8011294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8211160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8252624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8346196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8397338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8397339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622971-8538746
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcineurin,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response Element...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoprotein Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3536-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8622971-Amino Acid Sequence,
pubmed-meshheading:8622971-Base Sequence,
pubmed-meshheading:8622971-Calcineurin,
pubmed-meshheading:8622971-Calmodulin-Binding Proteins,
pubmed-meshheading:8622971-Cell Differentiation,
pubmed-meshheading:8622971-Child, Preschool,
pubmed-meshheading:8622971-Conserved Sequence,
pubmed-meshheading:8622971-Cyclic AMP,
pubmed-meshheading:8622971-Cyclic AMP Response Element Modulator,
pubmed-meshheading:8622971-DNA, Complementary,
pubmed-meshheading:8622971-DNA Primers,
pubmed-meshheading:8622971-DNA-Binding Proteins,
pubmed-meshheading:8622971-Genes, pX,
pubmed-meshheading:8622971-Human T-lymphotropic virus 1,
pubmed-meshheading:8622971-Humans,
pubmed-meshheading:8622971-Infant,
pubmed-meshheading:8622971-Interleukin-2,
pubmed-meshheading:8622971-Molecular Sequence Data,
pubmed-meshheading:8622971-Phosphoprotein Phosphatases,
pubmed-meshheading:8622971-Promoter Regions, Genetic,
pubmed-meshheading:8622971-Repressor Proteins,
pubmed-meshheading:8622971-Signal Transduction,
pubmed-meshheading:8622971-T-Lymphocytes,
pubmed-meshheading:8622971-Transcriptional Activation
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pubmed:year |
1996
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pubmed:articleTitle |
cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes.
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pubmed:affiliation |
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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