Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1996-6-18
pubmed:abstractText
The peptide-binding motif of HLA-A29, the predisposing allele for birdshot retinopathy, was determined after acid-elution of endogenous peptides from purified HLA-A29 molecules. Individual and pooled HPLC fractions were sequenced by Edman degradation. Major anchor residues could be defined as glutamate at the second position of the peptide and as tyrosine at the carboxyl terminus. In vitro binding of polyglycine synthetic peptides to purified HLA-A29 molecules also revealed the need for an auxiliary anchor residue at the third position, preferably phenylalanine. By using this motif, we synthesized six peptides from the retinal soluble antigen, a candidate autoantigen in autoimmune uveoretinitis. Their in vitro binding was tested on HLA-A29 and also on HLA-B44 and HLA-B61, two alleles sharing close peptide-binding motifs. Two peptides derived from the carboxyl-terminal sequence of the human retinal soluble antigen bound efficiently to HLA-A29. This study could contribute to the prediction of T-cell epitopes from retinal autoantigens implicated in birdshot retinopathy.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-1138855, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-1290750, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-1701801, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-1709722, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-1729172, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-1764641, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-1782566, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-1867297, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-2126195, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-2344622, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-2378377, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-2384017, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-2388036, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-2416842, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-2475283, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-2478623, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-2988124, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-3164688, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-3341436, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-3621983, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-6176653, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-6188154, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-6956239, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-7521859, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-7527444, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-7542198, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-7612235, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-7694588, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-7734418, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-7814893, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-7890324, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-7957552, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-8213969, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-8225441, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-8245441, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-8268130, http://linkedlifedata.com/resource/pubmed/commentcorrection/8622959-8475492
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3466-70
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
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