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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1996-6-18
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pubmed:abstractText |
Complement receptor 1 (CR1, CD35) and complement receptor 2 (CR2, CD21) have been implicated as regulators of B-cell activation. We explored the role of these receptors in the development of humoral immunity by generating CR1- and CR2-deficient mice using gene-targeting techniques. These mice have normal basal levels of IgM and of IgG isotypes. B- and T-cell development are overtly normal. Nevertheless, B-cell responses to low and high doses of a T-cell-dependent antigen are impaired with decreased titers of antigen-specific IgM and IgG isotypes. This defect is not complete because there is still partial activation of B lymphocytes during the primary immune response, with generation of splenic germinal centers and a detectable, although reduced, secondary antibody response. These data suggest that certain T-dependent antigens manifest an absolute dependence on complement receptors for the initiation of a normally robust immune response.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1378280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1386409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1431101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1695671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1708808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1712014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1717285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1718035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1730912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1826011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1828822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-1870982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-2139460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-2145366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-2269326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-2551147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-2665442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-2966205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-3156184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-3194019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-6356429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-6368693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-7524521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-7542548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-7543183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-7688513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-7737272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-7759885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8622941-8171322
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3357-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8622941-Animals,
pubmed-meshheading:8622941-Antibody Formation,
pubmed-meshheading:8622941-B-Lymphocytes,
pubmed-meshheading:8622941-Erythrocytes,
pubmed-meshheading:8622941-Gene Targeting,
pubmed-meshheading:8622941-Immunization,
pubmed-meshheading:8622941-Immunoglobulin G,
pubmed-meshheading:8622941-Immunoglobulin M,
pubmed-meshheading:8622941-Lymphocyte Activation,
pubmed-meshheading:8622941-Mice,
pubmed-meshheading:8622941-Mice, Knockout,
pubmed-meshheading:8622941-Receptors, Complement 3b,
pubmed-meshheading:8622941-Receptors, Complement 3d,
pubmed-meshheading:8622941-Sheep,
pubmed-meshheading:8622941-T-Lymphocytes
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pubmed:year |
1996
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pubmed:articleTitle |
Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.
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pubmed:affiliation |
Department of Internal Medicine and Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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