Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1996-6-18
|
| pubmed:abstractText |
Heredity non-polyposis colorectal cancer (HNPCC) is associated with an increased predisposition to colorectal cancer and extra-colonic cancers of the gastro-intestinal, urological and female reproductive tracts. These tumours are characterised by an underlying defect in DNA mismatch repair and exhibit numerous replication errors throughout the genome (RER+ phenotype). HNPCC-associated gastric tumours, and a subset of sporadic, distally-located gastric tumours exhibit this RER+ phenotype. It is recognised that proximal and distal gastric tumours exhibit distinct epidemiological features. In this study we investigated the occurrence of microsatellite instability in a series of 38 primary gastric adenocarcinomas, arising in the proximal stomach. A total of 138 microsatellite markers, comprising mainly dinucleotide and tetranucleotide repeat units and covering all autosomal arms, excluding acrocentric arms, were analysed. One tumour demonstrated somatic microsatellite alterations at 62% (26 of 42) of loci tested. A further 32 tumours demonstrated levels of microsatellite instability ranging from 0.8% (1 of 28)-11.4% (15 of 132) of loci tested. Five tumours demonstrated no microsatellite alterations at any of the loci tested. These findings suggest that a high percentage of proximal gastric carcinomas exhibit a low level of microsatellite alterations at dinucleotide and tetranucleotide repeat loci. However, ubiquitous somatic alterations at these loci, characteristic of HNPCC-associated tumours, occur in a relatively small proportion of tumours.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0950-9232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
18
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1653-62
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8622885-Adenocarcinoma,
pubmed-meshheading:8622885-Adult,
pubmed-meshheading:8622885-Aged,
pubmed-meshheading:8622885-Cardia,
pubmed-meshheading:8622885-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:8622885-DNA, Satellite,
pubmed-meshheading:8622885-DNA Repair,
pubmed-meshheading:8622885-Dinucleotide Repeats,
pubmed-meshheading:8622885-Female,
pubmed-meshheading:8622885-Gene Frequency,
pubmed-meshheading:8622885-Genetic Markers,
pubmed-meshheading:8622885-Humans,
pubmed-meshheading:8622885-Karyotyping,
pubmed-meshheading:8622885-Male,
pubmed-meshheading:8622885-Microsatellite Repeats,
pubmed-meshheading:8622885-Middle Aged,
pubmed-meshheading:8622885-Phenotype,
pubmed-meshheading:8622885-Stomach Neoplasms
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Widespread microsatellite instability occurs infrequently in adenocarcinoma of the gastric cardia.
|
| pubmed:affiliation |
Department of Medical Genetics, Queen's University of Belfast, Belfast City Hospital, N. Ireland.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|