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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9004
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pubmed:dateCreated |
1996-6-18
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pubmed:abstractText |
The term genetic anticipation is used to describe earlier onset of disease, increased severity, or both, in succeeding generations of families affected by a particular disease. This process has been linked with expanded genomic trinucleotide repeat regions in some neurological disorders. Crohn's disease, an inflammatory bowel disorder, has genetic influences, which remain undefined. We studied pairs of two-generation first-degree relatives with Crohn's disease to seek evidence for genetic anticipation in this disorder.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0140-6736
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
23
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pubmed:volume |
347
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
798-800
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8622336-Adolescent,
pubmed-meshheading:8622336-Adult,
pubmed-meshheading:8622336-Age of Onset,
pubmed-meshheading:8622336-Case-Control Studies,
pubmed-meshheading:8622336-Crohn Disease,
pubmed-meshheading:8622336-Female,
pubmed-meshheading:8622336-Genetic Predisposition to Disease,
pubmed-meshheading:8622336-Humans,
pubmed-meshheading:8622336-Male,
pubmed-meshheading:8622336-Regression Analysis,
pubmed-meshheading:8622336-Retrospective Studies,
pubmed-meshheading:8622336-Severity of Illness Index,
pubmed-meshheading:8622336-Trinucleotide Repeats
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pubmed:year |
1996
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pubmed:articleTitle |
Preliminary evidence for genetic anticipation in Crohn's disease.
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pubmed:affiliation |
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Multicenter Study
|