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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
10
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pubmed:dateCreated |
1996-6-20
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pubmed:abstractText |
Systemic lupus erythematosus is characterized by the production of Abs to ribonucleoproteins, including Ro (or SS-A) and La (or SS-B). The mechanism by which these autoantibodies arise is unknown. We have immunized rabbits with peptides from the sequence of the 60-kDa Ro. Animals so immunized not only produce Abs to the immunogen peptide, but also develop an autoimmune response to the entire 60-kDa Ro Ag. In about 20% of these animals, autoimmunity also spreads to the La Ag. Anti-native DNA was present in one of nine rabbits. All animals had anti-nuclear Ab, but even among those immunized with the same peptides, different patterns of immunofluorescence were found. Thus, among these outbred animals immunized with peptides from 60-kDa Ro, distinct serologic manifestations were present, showing heterogeneity in the development of autoimmunity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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|
pubmed:volume |
156
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
4059-66
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8621949-Amino Acid Sequence,
pubmed-meshheading:8621949-Animals,
pubmed-meshheading:8621949-Antibodies, Antinuclear,
pubmed-meshheading:8621949-Antigen Presentation,
pubmed-meshheading:8621949-Autoantigens,
pubmed-meshheading:8621949-Autoimmune Diseases,
pubmed-meshheading:8621949-Immunization,
pubmed-meshheading:8621949-Lupus Erythematosus, Systemic,
pubmed-meshheading:8621949-Molecular Sequence Data,
pubmed-meshheading:8621949-Molecular Weight,
pubmed-meshheading:8621949-Peptides,
pubmed-meshheading:8621949-RNA, Small Cytoplasmic,
pubmed-meshheading:8621949-Rabbits,
pubmed-meshheading:8621949-Ribonucleoproteins
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pubmed:year |
1996
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pubmed:articleTitle |
Immunization with short peptides from the sequence of the systemic lupus erythematosus-associated 60-kDa Ro autoantigen results in anti-Ro ribonucleoprotein autoimmunity.
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pubmed:affiliation |
Immunology and Arthritis Program, Oklahoma Medical Research Foundation, Oklahoma City 73014, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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