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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1996-6-18
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pubmed:abstractText |
We assessed the efficacy of recombinant human interleukin-1 receptor antagonist (rhIL-1ra) on brain injury and edema formation after permanent middle cerebral artery occlusion (MCAo) in the rat. Previous studies showed that low amounts of rhIL-1ra injected directly into the brain significantly decreased infarct size after MCAo or excitotoxic injury in rats. Peripheral administration of rhIL-1ra (100 mg/kg sc at 0, 4, 8, 12, and 18 h after MCAo) significantly inhibited infarct size, by 46% (P < 0.05), measured at 24h. This was greater than the effect of MK801 administered immediately after MCAo (4 mg/kg ip, 0 h) which did not significantly reduce infarct size. rhIL-1ra (100 mg/kg also significantly inhibited cerebral edema formation by 49% (p< 0.05 measured 24 h after MCAo, but did not reduce edema formation measured 2 h after MCAo, but did not reduce edema formation measured 2 h after MCAo. Inhibition of infarction by rhIL-1ra was dependent on dose and time of administration. Together the results demonstrate that peripherally administered rhIL-1ra at high doses is able to mimic the efficacy of low dose of rhIL-1ra administered directly into the brain in a rodent model of stroke and that protection observed with rhIL-1ra was better than that offered by MK801 in this model.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-4886
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
206-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8620919-Animals,
pubmed-meshheading:8620919-Blood Glucose,
pubmed-meshheading:8620919-Brain Damage, Chronic,
pubmed-meshheading:8620919-Brain Edema,
pubmed-meshheading:8620919-Brain Ischemia,
pubmed-meshheading:8620919-Cerebral Infarction,
pubmed-meshheading:8620919-Dizocilpine Maleate,
pubmed-meshheading:8620919-Humans,
pubmed-meshheading:8620919-Injections, Intravenous,
pubmed-meshheading:8620919-Injections, Subcutaneous,
pubmed-meshheading:8620919-Male,
pubmed-meshheading:8620919-Rats,
pubmed-meshheading:8620919-Rats, Sprague-Dawley,
pubmed-meshheading:8620919-Receptors, Interleukin-1,
pubmed-meshheading:8620919-Recombinant Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Peripheral administration of Interleukin-1 Receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat.
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pubmed:affiliation |
Department of Preclinical Pharmacology, Amgen Inc, Boulder, Colorado 80301, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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