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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-6-17
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pubmed:abstractText |
The Eph-related receptor tyrosine kinase gene, Cek-8, is expressed in mesenchyme at the tip of chick limb buds, with high levels of transcripts posteriorly and apically but fading out anteriorly. Expression of Cek-8 in distal mesenchyme is regulated by apical ridge- and FGF-polarising signals and retinoic acid, and is uniform across the anteroposterior axis in talpid3 mutants. These data indicate that Cek-8 expression responds to regulatory signals during limb patterning and suggest that this receptor tyrosine kinase may have a role in coordinating responses to signals in the progress zone of early buds. Later on in limb development, Cek-8 expression is associated with cell condensations that form tendons and their attachments to cartilage rudiments and then in developing feather buds.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, EphA4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1147-55
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8620841-Animals,
pubmed-meshheading:8620841-Bone Morphogenetic Proteins,
pubmed-meshheading:8620841-Cell Communication,
pubmed-meshheading:8620841-Chick Embryo,
pubmed-meshheading:8620841-Feathers,
pubmed-meshheading:8620841-Fibroblast Growth Factor 2,
pubmed-meshheading:8620841-Gene Expression Regulation, Developmental,
pubmed-meshheading:8620841-Growth Substances,
pubmed-meshheading:8620841-Limb Buds,
pubmed-meshheading:8620841-Mesoderm,
pubmed-meshheading:8620841-Mice,
pubmed-meshheading:8620841-Mice, Inbred C57BL,
pubmed-meshheading:8620841-Microspheres,
pubmed-meshheading:8620841-Mutation,
pubmed-meshheading:8620841-Neuropeptides,
pubmed-meshheading:8620841-Proteins,
pubmed-meshheading:8620841-RNA, Messenger,
pubmed-meshheading:8620841-Receptor, EphA4,
pubmed-meshheading:8620841-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:8620841-Tendons,
pubmed-meshheading:8620841-Tretinoin
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pubmed:year |
1996
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pubmed:articleTitle |
Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds.
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pubmed:affiliation |
Division of Developmental Neurobiology, National Institute for Medical Research, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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