Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1996-6-14
pubmed:abstractText
The ALL1 gene is found rearranged in approximately 10% of acute lymphoblastic leukemias and in over 5% of acute myeloid leukemias. The gene undergoes fusion with either a variety of partner genes located on different chromosomes or with itself. To further characterize the role of the ALL1 gene in the leukemogenic process, and possibly in solid malignancies, we defined its complete genomic structure. The gene, which spans a region on chromosome band 11q23 approximately 90 kb in length, consists of 36 exons, ranging in size from 65 bp to 4249 bp. The determination of intronic sequences flanking the exon boundaries will allow the determination of whether point mutations may be responsible for inactivation of the gene in solid tumors showing loss of heterozygosity at region 11q23.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1766-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:8620491-Base Sequence, pubmed-meshheading:8620491-Chromosome Mapping, pubmed-meshheading:8620491-Chromosomes, Human, Pair 11, pubmed-meshheading:8620491-DNA, Complementary, pubmed-meshheading:8620491-DNA Primers, pubmed-meshheading:8620491-DNA-Binding Proteins, pubmed-meshheading:8620491-Exons, pubmed-meshheading:8620491-Gene Rearrangement, pubmed-meshheading:8620491-Humans, pubmed-meshheading:8620491-Leukemia, Myeloid, pubmed-meshheading:8620491-Molecular Sequence Data, pubmed-meshheading:8620491-Myeloid-Lymphoid Leukemia Protein, pubmed-meshheading:8620491-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:8620491-Proto-Oncogenes, pubmed-meshheading:8620491-Restriction Mapping, pubmed-meshheading:8620491-Transcription Factors, pubmed-meshheading:8620491-Zinc Fingers
pubmed:year
1996
pubmed:articleTitle
Complete exon structure of the ALL1 gene.
pubmed:affiliation
Kimmel Cancer Institute, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't