Linked Life Data

8618446

Source:http://linkedlifedata.com/resource/pubmed/id/8618446

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-6-13
pubmed:abstractText
We previously reported the favorable prognosis associated with positive peanut agglutinin (PNA) binding in childhood T cell acute lymphoblastic leukemia (ALL), and hypothesized that this may be related to glucocorticoid sensitivity (Veerman et al. Cancer Res 1985, 45: 1890). The purposes of this prospective study involving 202 children with newly diagnosed ALL were to determine the relationship between PNA binding and (1) immunophenotype; (2) in vitro resistance to prednisolone (PRD) and dexamethasone and other drugs; (3) clinical response to a systemic PRD monotherapy (plus one intrathecal injection with methotrexate); and (4) multidrug chemotherapy. PNA positivity was more frequent in T cell ALL (65% of 43 cases) than in pro-B (0% of seven cases), common (17% of 106 cases) and pre-B (16% of 45 cases) ALL (P < 0.001). PNA binding was not associated with in vitro resistance to PRD or dexamethasone. However, in 38 evaluable T cell ALL patients, nine of 13 PNA-negative cases were clinically poor responders to PRD, while all 25 PNA-positive cases were good responders to PRD clinically (P < 0.0001). The four clinically poor PRD responders with B cell precursor (BCP)-ALL were also PNA negative. Within T cell ALL, PNA-positive patients had a 3.4-fold (95% Cl, 1.1-10.4, P = 0.03) lower relative risk of any event, than PNA-negative patients. Within BCP-ALL, PNA binding was not of prognostic significance. In conclusion, PNA positivity, especially frequent in T cell ALL, is a marker for a subgroup of childhood ALL patients who are very likely to respond well to systemic PRD 'monotherapy'. In addition, PNA positivity is a favorable prognostic factor in T cell ALL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0887-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
675-81
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:8618446-Adolescent, pubmed-meshheading:8618446-Antineoplastic Agents, Hormonal, pubmed-meshheading:8618446-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:8618446-Arachis hypogaea, pubmed-meshheading:8618446-Bone Marrow, pubmed-meshheading:8618446-Child, pubmed-meshheading:8618446-Child, Preschool, pubmed-meshheading:8618446-Dexamethasone, pubmed-meshheading:8618446-Drug Resistance, Neoplasm, pubmed-meshheading:8618446-Female, pubmed-meshheading:8618446-Humans, pubmed-meshheading:8618446-Immunophenotyping, pubmed-meshheading:8618446-Infant, pubmed-meshheading:8618446-Injections, Spinal, pubmed-meshheading:8618446-Lectins, pubmed-meshheading:8618446-Leukemia-Lymphoma, Adult T-Cell, pubmed-meshheading:8618446-Male, pubmed-meshheading:8618446-Methotrexate, pubmed-meshheading:8618446-Peanut Agglutinin, pubmed-meshheading:8618446-Plant Lectins, pubmed-meshheading:8618446-Predictive Value of Tests, pubmed-meshheading:8618446-Prednisolone, pubmed-meshheading:8618446-Probability, pubmed-meshheading:8618446-Prognosis, pubmed-meshheading:8618446-Risk Factors, pubmed-meshheading:8618446-Tumor Cells, Cultured
pubmed:year
1996
pubmed:articleTitle
Prognostic significance of peanut agglutinin binding in childhood acute lymphoblastic leukemia.
pubmed:affiliation
Department of Pediatrics, Free University Hospital, Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't