Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1996-6-3
|
| pubmed:abstractText |
The role of tachykinins in the potentiation of antigen-evoked bronchoconstriction induced by inhalation of cold air was studied in guinea pigs. Cold air was delivered through a tracheal cannula to anesthetized, artificially ventilated guinea pigs sensitized with ovalbumin and pretreated with atropine (1.4 micromol/kg). Inhalation of cold air increased total pulmonary resistance (RL) in a time-dependent manner; inhalation of cold air for 10 or 15 minutes, but not for 5 minutes, produced a significant increase in RL. Aerosolized ovalbumin (5 breaths) increased RL in a dose-dependent manner (0.5% to 5%). Inhalation of cold air for 5 minutes significantly enhanced both the peak and the duration of the increase in RL induced by 0.5% ovalbumin. The tachykinin neurokinin 2-receptor antagonist, SR 48968 (0.3 micromol/kg intravenously) inhibited both the peak and the duration of the bronchoconstriction induced by 5-minute inhalation of cold air and ovalbumin (0.5%), whereas it did not affect the response to ovalbumin (0.5%) alone. These findings suggest that exposure to cold air potentiates the bronchoconstriction response to antigen and that this potentiation is mediated by tachykinin release from sensory nerves.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0091-6749
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
97
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
756-60
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8613631-Airway Resistance,
pubmed-meshheading:8613631-Animals,
pubmed-meshheading:8613631-Antigens,
pubmed-meshheading:8613631-Bronchoconstriction,
pubmed-meshheading:8613631-Cold Temperature,
pubmed-meshheading:8613631-Drug Synergism,
pubmed-meshheading:8613631-Guinea Pigs,
pubmed-meshheading:8613631-Immunization,
pubmed-meshheading:8613631-Male,
pubmed-meshheading:8613631-Ovalbumin,
pubmed-meshheading:8613631-Tachykinins
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Tachykinins mediate the potentiation of antigen-induced bronchoconstriction by cold air in guinea pigs.
|
| pubmed:affiliation |
Cardiovascular Research Institute, University of California San Francisco 94143-0130, USA.
|
| pubmed:publicationType |
Journal Article
|