Linked Life Data

8612567

Source:http://linkedlifedata.com/resource/pubmed/id/8612567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-6-5
pubmed:abstractText
This study investigated the role of the circadian timing system (CTS) in photoperiodic time measurement by examining the response of the tau mutant hamster to programmed infusions of melatonin. The mutation is a single Mendelian gene defect which accelerates circadian period from 24 h in the wild-type (WT) to 20 h in the homozygote. If the CTS does not contribute to the photoperiodic interpretation of the melatonin signal, then the tau mutation would not influence photoperiodic responses of pinealectomised (PX) animals to systemic infusions of melatonin (10 h) once every 20, 24 or 25 h, mimics short-daylengths and causes gonadal involution. More ( < 18 h) or less ( > 25 h) frequent signals are ineffective. In this study, taus which received melatonin (10 h) once every 16 or 20 h exhibited significant gonadal atrophy relative to saline controls, whereas infusions of melatonin every 24 or 28 h were ineffective. Serum concentrations of LH and PRL were also significantly reduced in both the 16 and 20 h, but not 24 and 28 h groups. The tau mutant hamster may therefore respond to a different and higher ranger of melatonin signal frequencies than those reported for WTs. The 4 h shift in the frequency-response function correlates with the altered circadian period and suggests that the CTS contributes to the photoperiodic interpretation of a series of melatonin signals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
137
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2183-6
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The tau mutation in the Syrian hamster alters the photoperiodic responsiveness of the gonadal axis to melatonin signal frequency.
pubmed:affiliation
School of Biological Sciences, University of Manchester, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't