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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-6-5
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pubmed:databankReference |
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pubmed:abstractText |
In C. elegans, the anchor cell signal induces Pn.p cells to form the vulva by activating a conserved receptor tyrosine kinase pathway. lin-2 and lin-7 mutants exhibit a vulvaless phenotype similar to the phenotype observed when this signaling pathway is defective. We have found that LIN-7 is a cell junction-associated protein that binds to the LET-23 receptor tyrosine kinase. LET-23 is also localized to the cell junctions, and both LIN-2 and LIN-7 are required for this localization. LET-23 overexpression rescues the lin-2 or lin-7 vulvaless phenotype, suggesting that increased receptor density can compensate for mislocalization. These results suggest that proper localization of LET-23 receptor to the Pn.p cell junctions is required for signaling activity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lin-2 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/let-23 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/lin-10 protein, C elegans
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
195-204
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8612272-Animals,
pubmed-meshheading:8612272-Base Sequence,
pubmed-meshheading:8612272-Caenorhabditis elegans,
pubmed-meshheading:8612272-Caenorhabditis elegans Proteins,
pubmed-meshheading:8612272-Cloning, Molecular,
pubmed-meshheading:8612272-Embryonic Induction,
pubmed-meshheading:8612272-Epithelium,
pubmed-meshheading:8612272-Female,
pubmed-meshheading:8612272-Genes, Helminth,
pubmed-meshheading:8612272-Helminth Proteins,
pubmed-meshheading:8612272-Intercellular Junctions,
pubmed-meshheading:8612272-Membrane Proteins,
pubmed-meshheading:8612272-Molecular Sequence Data,
pubmed-meshheading:8612272-Mutation,
pubmed-meshheading:8612272-Phenotype,
pubmed-meshheading:8612272-Protein Structure, Tertiary,
pubmed-meshheading:8612272-Proteins,
pubmed-meshheading:8612272-Receptor, Epidermal Growth Factor,
pubmed-meshheading:8612272-Sequence Homology, Amino Acid,
pubmed-meshheading:8612272-Signal Transduction,
pubmed-meshheading:8612272-Vulva
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pubmed:year |
1996
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pubmed:articleTitle |
LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction.
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pubmed:affiliation |
Department of Developmental Biology, Stanford University Medical School, California 94305-5427, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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