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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-6-5
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pubmed:abstractText |
The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, involved in de novo cholesterol synthesis and cell-cycle progression, was identified as a potential mediator of the growth inhibitory effects of retinoic acid on human neuroblastoma. Lovastatin, a nonreversible inhibitor of HMG-CoA reductase, induced extensive cytotoxicity that was restricted to drug-resistant P-glycoprotein-expressing neuroblastoma cell lines. This response was potentiated by dibutyryl cyclic AMP but not retinoic acid. Patients with advanced-stage metastatic neuroblastoma often display an acquired chemoresistant phenotype, which may in part be mediated by P-glycoprotein. Our studies support the application or use of HMG-CoA reductase inhibitors as potential therapeutic agents in the treatment of these patients who are refractory to chemotherapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
326-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8612233-Base Sequence,
pubmed-meshheading:8612233-Bucladesine,
pubmed-meshheading:8612233-DNA Primers,
pubmed-meshheading:8612233-Enzyme Inhibitors,
pubmed-meshheading:8612233-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:8612233-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8612233-Humans,
pubmed-meshheading:8612233-Hydroxymethylglutaryl CoA Reductases,
pubmed-meshheading:8612233-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:8612233-Lovastatin,
pubmed-meshheading:8612233-Molecular Sequence Data,
pubmed-meshheading:8612233-Neuroblastoma,
pubmed-meshheading:8612233-P-Glycoprotein,
pubmed-meshheading:8612233-Tretinoin,
pubmed-meshheading:8612233-Tumor Cells, Cultured
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pubmed:year |
1996
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pubmed:articleTitle |
HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: lovastatin specifically targets P-glycoprotein-expressing cells.
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pubmed:affiliation |
Department of Pathology, The Hospital for Sick Children, Toronto, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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