Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1996-6-6
|
| pubmed:databankReference | |
| pubmed:abstractText |
In our search for cell surface markers expressed on hematopoietic stem cells and/or very early progenitor cells we found that the Joro 177 monoclonal antibody (MoAb) bound to most hematopoietic cells in day 8/8.5 yolk sac, day 12 fetal liver, and day 13 fetal thymocytes; it stained hematopoietic stem cells and less immature lymphoid, myeloid, and erythroid-lineage cells, but not most thymocytes and splenic lymphocytes in adult mice. Joro 177 MoAb stimulated tyrosine phosphorylation of an integral of 124-kD protein and induced homotypic aggregation of lymphoid progenitor cells. Importantly, Joro 177 MoAb inhibited cell survival/growth and consequently the generation of lymphoid, myeloid, and erythroid lineage cells in vitro from early Lin- hematopoietic precursors. Joro 177 MoAb induced apoptosis of hematopoietic progenitor cells. Molecular cloning and expression indicated that Joro 177 MoAb recognizes a type II transmembrane protein, which is the mouse homologue of the human CD98 heavy chain gene. We suggest that CD98 is a cell membrane receptor involved in the control of cell survival/death of hematopoietic cells.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD98,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
87
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3676-87
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8611692-Amino Acid Sequence,
pubmed-meshheading:8611692-Animals,
pubmed-meshheading:8611692-Antibodies, Monoclonal,
pubmed-meshheading:8611692-Antigens, CD,
pubmed-meshheading:8611692-Antigens, CD98,
pubmed-meshheading:8611692-Biological Markers,
pubmed-meshheading:8611692-Carrier Proteins,
pubmed-meshheading:8611692-Cell Differentiation,
pubmed-meshheading:8611692-Cell Survival,
pubmed-meshheading:8611692-Hematopoiesis,
pubmed-meshheading:8611692-Hematopoietic Stem Cells,
pubmed-meshheading:8611692-Humans,
pubmed-meshheading:8611692-Membrane Glycoproteins,
pubmed-meshheading:8611692-Mice,
pubmed-meshheading:8611692-Mice, Inbred C3H,
pubmed-meshheading:8611692-Mice, Inbred C57BL,
pubmed-meshheading:8611692-Molecular Sequence Data,
pubmed-meshheading:8611692-Sequence Alignment
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
CD98: a type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells.
|
| pubmed:affiliation |
Department of Immunology, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|