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rdf:type |
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lifeskim:mentions |
umls-concept:C0002345,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035696,
umls-concept:C0079411,
umls-concept:C0117720,
umls-concept:C0205314,
umls-concept:C0205419,
umls-concept:C0376315,
umls-concept:C0679622,
umls-concept:C2700640
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pubmed:issue |
1
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pubmed:dateCreated |
1996-6-4
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pubmed:databankReference |
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pubmed:abstractText |
We isolated rat FGF-5 cDNA and its variant from the embryo. The FGF-5 cDNA encodes a protein of 266 amino acid residues. The variant cDNA encodes a protein of 121 amino acid residues, the N-terminal 117-amino acid sequence of which is identical to that of FGF-5. Thus the variant cDNA encodes a novel truncated form of FGF-5. The rat FGF-5 gene consists of three exons (exons 1-3). The variant cDNA lacks the nucleotide sequence of exon 2, indicating that the variant mRNA is generated by alternative splicing. The variant mRNA as well as the FGF-5 mRNA was detected in the embryo and adult brain. This is the first description of the mRNA for a truncated form of FGF within the FGF family.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Fetal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fgf5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fgf5 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 5,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
1306
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-3
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8611621-Age Factors,
pubmed-meshheading:8611621-Amino Acid Sequence,
pubmed-meshheading:8611621-Animals,
pubmed-meshheading:8611621-Base Sequence,
pubmed-meshheading:8611621-Brain,
pubmed-meshheading:8611621-DNA, Complementary,
pubmed-meshheading:8611621-Fetal Proteins,
pubmed-meshheading:8611621-Fibroblast Growth Factor 5,
pubmed-meshheading:8611621-Fibroblast Growth Factors,
pubmed-meshheading:8611621-Gene Expression Regulation, Developmental,
pubmed-meshheading:8611621-Genetic Variation,
pubmed-meshheading:8611621-Mice,
pubmed-meshheading:8611621-Molecular Sequence Data,
pubmed-meshheading:8611621-Nerve Tissue Proteins,
pubmed-meshheading:8611621-Organ Specificity,
pubmed-meshheading:8611621-RNA, Messenger,
pubmed-meshheading:8611621-RNA Splicing,
pubmed-meshheading:8611621-Rats,
pubmed-meshheading:8611621-Sequence Alignment,
pubmed-meshheading:8611621-Sequence Homology, Amino Acid,
pubmed-meshheading:8611621-Species Specificity
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pubmed:year |
1996
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pubmed:articleTitle |
The rat FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated form of FGF-5.
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pubmed:affiliation |
Department of Genetic Biochemistry, Kyoto University Faculty of Pharmaceutical Sciences, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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