|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1996-5-24
|
|
pubmed:abstractText |
The human immunodeficiency virus type 1 (HIV-1) Rev protein is required for nuclear export of late HIV-1 mRNAs. This function is dependent on the mutationally defined Rev activation domain, which also forms a potent nuclear export signal. Transcription factor IIIA (TFIIIA) binds to 5S rRNA transcripts and this interaction has been proposed to play a role in the efficient nuclear export of 5S rRNA in amphibian oocytes. Here it is reported that amphibian TFIIIA proteins contain a sequence element with homology to the Rev activation domain that effectively substitutes for this domain in inducing the nuclear export of late HIV-1 mRNAs. It is further demonstrated that this TFIIIA sequence element functions as a protein nuclear export signal in both human cells and frog oocytes. Thus, this shared protein motif may play an analogous role in mediating the nuclear export of both late HIV-1 RNAs and 5S rRNA transcripts.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-1398134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-1548784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-1645796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-1871141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-1920623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2015625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2072452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2217212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2406030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2481237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2556643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2704072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2736624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2752419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2784194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-2784208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-284338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-3012355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-3638988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-6153931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-6210149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-7001457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-7537634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-7543368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-7634336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-7634337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-7634338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-7637788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-8076606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-8105371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-8642662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8610146-8819566
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, rev,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal, 5S,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor TFIIIA,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/rev Gene Products, Human...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
2
|
|
pubmed:volume |
93
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2936-40
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:8610146-Amino Acid Sequence,
pubmed-meshheading:8610146-Animals,
pubmed-meshheading:8610146-Bufonidae,
pubmed-meshheading:8610146-Cell Nucleus,
pubmed-meshheading:8610146-DNA-Binding Proteins,
pubmed-meshheading:8610146-Female,
pubmed-meshheading:8610146-Gene Expression Regulation,
pubmed-meshheading:8610146-Gene Products, rev,
pubmed-meshheading:8610146-HIV-1,
pubmed-meshheading:8610146-HIV-2,
pubmed-meshheading:8610146-Humans,
pubmed-meshheading:8610146-Molecular Sequence Data,
pubmed-meshheading:8610146-Oocytes,
pubmed-meshheading:8610146-RNA, Messenger,
pubmed-meshheading:8610146-RNA, Ribosomal, 5S,
pubmed-meshheading:8610146-Recombinant Fusion Proteins,
pubmed-meshheading:8610146-Sequence Homology, Amino Acid,
pubmed-meshheading:8610146-Species Specificity,
pubmed-meshheading:8610146-Transcription, Genetic,
pubmed-meshheading:8610146-Transcription Factor TFIIIA,
pubmed-meshheading:8610146-Transcription Factors,
pubmed-meshheading:8610146-Xenopus laevis,
pubmed-meshheading:8610146-rev Gene Products, Human Immunodeficiency Virus
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
|
