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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1996-5-24
|
| pubmed:abstractText |
Lesions that are histologically classified as precursors of cervical cancer, which are often referred to as squamous intraepithelial lesions (SILs), represent a heterogeneous clinical entity that can be associated with many different types of human papillomaviruses (HPVs) and have a variable biologic behavior. Approximately one half of low-grade SILs behave as non-neoplastic, productive viral lesions that frequently regress spontaneously, whereas the other half behave as neoplasms and either persist or progress to a histologically higher grade lesion. Identification of biomarkers that reliably differentiate those low-grade SILs with the properties of a non-neoplastic viral infection from those with the properties of neoplasia would provide a more rational basis for decisions about disease management. Since monoclonality is a hallmark of neoplasia irrespective or organ site, clonal status might represent one such biomarker.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0027-8874
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
88
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
355-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8609644-Alleles,
pubmed-meshheading:8609644-Base Sequence,
pubmed-meshheading:8609644-Carcinoma, Squamous Cell,
pubmed-meshheading:8609644-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:8609644-DNA, Viral,
pubmed-meshheading:8609644-Dosage Compensation, Genetic,
pubmed-meshheading:8609644-Female,
pubmed-meshheading:8609644-Formaldehyde,
pubmed-meshheading:8609644-Humans,
pubmed-meshheading:8609644-Molecular Sequence Data,
pubmed-meshheading:8609644-Papillomaviridae,
pubmed-meshheading:8609644-Papillomavirus Infections,
pubmed-meshheading:8609644-Paraffin Embedding,
pubmed-meshheading:8609644-Polymerase Chain Reaction,
pubmed-meshheading:8609644-Tissue Fixation,
pubmed-meshheading:8609644-Tumor Virus Infections,
pubmed-meshheading:8609644-Uterine Cervical Neoplasms
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Association between human papillomavirus type and clonal status of cervical squamous intraepithelial lesions.
|
| pubmed:affiliation |
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York 10032, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|