| pubmed-article:8609427 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8609427 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8609427 | lifeskim:mentions | umls-concept:C0004364 | lld:lifeskim |
| pubmed-article:8609427 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:8609427 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8609427 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:8609427 | lifeskim:mentions | umls-concept:C0314657 | lld:lifeskim |
| pubmed-article:8609427 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:8609427 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8609427 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8609427 | pubmed:dateCreated | 1996-5-29 | lld:pubmed |
| pubmed-article:8609427 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8609427 | pubmed:abstractText | Lupus-prone mice show reduced production of TNF-alpha and, upon long-term treatment with recombinant TNF-alpha, significant protection from disease development. Mutational analysis of the 5'-untranslated region (UTR) and 3'-UTR of the mouse TNF-alpha gene reveals a marked degree of polymorphism. Transient expression experiments in the RAW 264.7 macrophage-like cell line using the luciferase reporter system suggest an important role for the mutations in the 3'-UTR in the biosynthesis of TNF-alpha, and provide a molecular explanation for the reduced TNF-alpha production in lupus-prone NZW mice. | lld:pubmed |
| pubmed-article:8609427 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8609427 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8609427 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8609427 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8609427 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8609427 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8609427 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8609427 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8609427 | pubmed:author | pubmed-author:LeeS KSK | lld:pubmed |
| pubmed-article:8609427 | pubmed:author | pubmed-author:StrassmannGG | lld:pubmed |
| pubmed-article:8609427 | pubmed:author | pubmed-author:JacobC OCO | lld:pubmed |
| pubmed-article:8609427 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8609427 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8609427 | pubmed:volume | 156 | lld:pubmed |
| pubmed-article:8609427 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8609427 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8609427 | pubmed:pagination | 3043-50 | lld:pubmed |
| pubmed-article:8609427 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8609427 | pubmed:meshHeading | pubmed-meshheading:8609427-... | lld:pubmed |
| pubmed-article:8609427 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8609427 | pubmed:articleTitle | Mutational analysis of TNF-alpha gene reveals a regulatory role for the 3'-untranslated region in the genetic predisposition to lupus-like autoimmune disease. | lld:pubmed |
| pubmed-article:8609427 | pubmed:affiliation | Department of Medicine, University of Southern California School of Medicine, Los Angeles, CA 90033, USA. | lld:pubmed |
| pubmed-article:8609427 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8609427 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8609427 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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