| pubmed-article:8608639 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8608639 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8608639 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8608639 | lifeskim:mentions | umls-concept:C0034805 | lld:lifeskim |
| pubmed-article:8608639 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8608639 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:8608639 | lifeskim:mentions | umls-concept:C2709199 | lld:lifeskim |
| pubmed-article:8608639 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8608639 | pubmed:dateCreated | 1996-5-28 | lld:pubmed |
| pubmed-article:8608639 | pubmed:abstractText | Susceptibility to herpes virus infections has been described in experimental animals depleted of NK cells and in patients with defective NK cell function. We have identified a child with recurrent infections, especially with herpes simplex virus, who had a decreased number of CD56(+)CD3(-) NK cells in circulation. Her NK cells expressed an altered form of the Fc receptor for IgG type IIIA (Fc gamma RIIIA or CD16-II) which was not reactive with the anti-CD16-II MoAb B73.1. Sequence analysis revealed the patient to be homozygous for a T to A substitution at position 230 of CD16-II cDNA, predicting a Leu(66) to His(66) change in the first immunoglobulin domain of CD16-II at the B73.1 recognition site. Spontaneous NK cell activity of the patient's peripheral blood mononuclear cells (PBMC) was markedly decreased, while antibody-dependent cellular cytotoxicity (ADCC) was unaffected. These results suggest that this child suffers from a defect affecting the development and function of NK cells, resulting in NK cytopenia and clinically significant immunodeficiency. The role of the CD16-II mutant in the pathogenesis of the patient's NK cell deficiency is discussed. | lld:pubmed |
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| pubmed-article:8608639 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8608639 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8608639 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8608639 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8608639 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8608639 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:8608639 | pubmed:author | pubmed-author:GehaRR | lld:pubmed |
| pubmed-article:8608639 | pubmed:author | pubmed-author:FinbergRR | lld:pubmed |
| pubmed-article:8608639 | pubmed:author | pubmed-author:ChanMM | lld:pubmed |
| pubmed-article:8608639 | pubmed:author | pubmed-author:MoodyCC | lld:pubmed |
| pubmed-article:8608639 | pubmed:author | pubmed-author:ChatilaTT | lld:pubmed |
| pubmed-article:8608639 | pubmed:author | pubmed-author:JawaharSS | lld:pubmed |
| pubmed-article:8608639 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8608639 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:8608639 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8608639 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8608639 | pubmed:pagination | 408-13 | lld:pubmed |
| pubmed-article:8608639 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8608639 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8608639 | pubmed:articleTitle | Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). | lld:pubmed |
| pubmed-article:8608639 | pubmed:affiliation | Division of Immunology, The Children's Hospital, Boston, MA, USA. | lld:pubmed |
| pubmed-article:8608639 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8608639 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8608639 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:8608639 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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