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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-5-28
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pubmed:abstractText |
Susceptibility to herpes virus infections has been described in experimental animals depleted of NK cells and in patients with defective NK cell function. We have identified a child with recurrent infections, especially with herpes simplex virus, who had a decreased number of CD56(+)CD3(-) NK cells in circulation. Her NK cells expressed an altered form of the Fc receptor for IgG type IIIA (Fc gamma RIIIA or CD16-II) which was not reactive with the anti-CD16-II MoAb B73.1. Sequence analysis revealed the patient to be homozygous for a T to A substitution at position 230 of CD16-II cDNA, predicting a Leu(66) to His(66) change in the first immunoglobulin domain of CD16-II at the B73.1 recognition site. Spontaneous NK cell activity of the patient's peripheral blood mononuclear cells (PBMC) was markedly decreased, while antibody-dependent cellular cytotoxicity (ADCC) was unaffected. These results suggest that this child suffers from a defect affecting the development and function of NK cells, resulting in NK cytopenia and clinically significant immunodeficiency. The role of the CD16-II mutant in the pathogenesis of the patient's NK cell deficiency is discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-1692080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-1703781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-1710251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-1910686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2139697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2471777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2521732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2526846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2531918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2531919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2553809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2642532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2967435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2967436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-2981954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-6233371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-6309965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-6945311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-7512596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8608639-7621077
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
408-13
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8608639-Antibodies, Monoclonal,
pubmed-meshheading:8608639-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:8608639-Base Sequence,
pubmed-meshheading:8608639-Child, Preschool,
pubmed-meshheading:8608639-Epitopes,
pubmed-meshheading:8608639-Female,
pubmed-meshheading:8608639-Herpesviridae Infections,
pubmed-meshheading:8608639-Humans,
pubmed-meshheading:8608639-Immunologic Deficiency Syndromes,
pubmed-meshheading:8608639-Killer Cells, Natural,
pubmed-meshheading:8608639-Molecular Sequence Data,
pubmed-meshheading:8608639-Otitis Media,
pubmed-meshheading:8608639-Phenotype,
pubmed-meshheading:8608639-Receptors, IgG,
pubmed-meshheading:8608639-Sinusitis
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pubmed:year |
1996
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pubmed:articleTitle |
Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II).
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pubmed:affiliation |
Division of Immunology, The Children's Hospital, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports,
Research Support, Non-U.S. Gov't
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