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rdf:type |
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lifeskim:mentions |
umls-concept:C0008013,
umls-concept:C0010453,
umls-concept:C0024432,
umls-concept:C0027950,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205314,
umls-concept:C0282554,
umls-concept:C0679622,
umls-concept:C0680022,
umls-concept:C1332652,
umls-concept:C1705593,
umls-concept:C2003941
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pubmed:issue |
3
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pubmed:dateCreated |
1996-5-20
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pubmed:abstractText |
Neutrophil chemotactic factors (chemokines) have been purified from conditioned medium of lipopolysaccharide (LPS)-stimulated rat macrophages in culture. The LPS-stimulated macrophages produced one acidic chemokine, rat macrophage inflammatory protein (MIP)-1alpha, and four basic chemokines, cytokine-induced neutrophil chemoattractant (CINC)-1. CINC-2alpha, CINC-2beta and CINC-3/rat MIP-2. CINC-2alpha, a novel chemokine recently isolated from conditioned medium of rat granulation-tissue culture, was the major chemoattractant among these four basic chemokines. The results suggest that CINC-2alpha is produced by activated macrophages in vivo and plays an important role in the infiltration of neutrophils into inflammatory sites in rats
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Gm1960 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
220
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
945-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8607872-Amino Acid Sequence,
pubmed-meshheading:8607872-Animals,
pubmed-meshheading:8607872-Cells, Cultured,
pubmed-meshheading:8607872-Chemokine CXCL1,
pubmed-meshheading:8607872-Chemokine CXCL2,
pubmed-meshheading:8607872-Chemokines,
pubmed-meshheading:8607872-Chemokines, CXC,
pubmed-meshheading:8607872-Chemotactic Factors,
pubmed-meshheading:8607872-Chemotaxis, Leukocyte,
pubmed-meshheading:8607872-Culture Media, Conditioned,
pubmed-meshheading:8607872-Growth Substances,
pubmed-meshheading:8607872-Humans,
pubmed-meshheading:8607872-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:8607872-Lipopolysaccharides,
pubmed-meshheading:8607872-Macrophages, Peritoneal,
pubmed-meshheading:8607872-Male,
pubmed-meshheading:8607872-Molecular Sequence Data,
pubmed-meshheading:8607872-Neutrophils,
pubmed-meshheading:8607872-Rats,
pubmed-meshheading:8607872-Rats, Wistar,
pubmed-meshheading:8607872-Sequence Homology, Amino Acid
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pubmed:year |
1996
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pubmed:articleTitle |
Cytokine-induced neutrophil chemoattractant (CINC)-2 alpha, a novel member of rat GRO/CINCs, is a predominant chemokine produced by lipopolysaccharide-stimulated rat macrophages in culture.
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pubmed:affiliation |
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Toyoma Medical and Pharmaceutical University, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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