Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1996-5-20
|
| pubmed:abstractText |
Long-term depression (LTD) was studied in hippocampal slices from neonatal rats at the synapse between CA3 and CA1 pyramidal neurons. The induction of LTD requires the pairing of Ca2+ influx into the postsynaptic CA1 neuron through voltage-gated calcium channels with activation of metabotropic glutamate receptors. The expression of this LTD is at least partly presynaptic, implying the need for a retrograde messenger. We present evidence that arachidonic acid might serve such a function. Thus, arachidonic acid applications simulate LTD whereas blockade of arachidonic acid release inhibits LTD.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0028-3908
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1581-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8606806-Animals,
pubmed-meshheading:8606806-Arachidonic Acid,
pubmed-meshheading:8606806-Calcium Channels,
pubmed-meshheading:8606806-Electrophysiology,
pubmed-meshheading:8606806-Neuronal Plasticity,
pubmed-meshheading:8606806-Pyramidal Cells,
pubmed-meshheading:8606806-Rats,
pubmed-meshheading:8606806-Receptors, Metabotropic Glutamate
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Hippocampal long-term depression: arachidonic acid as a potential retrograde messenger.
|
| pubmed:affiliation |
Department of Pharmacology, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|