Linked Life Data

8606786

Source:http://linkedlifedata.com/resource/pubmed/id/8606786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1996-5-20
pubmed:abstractText
Synaptotagmins and synapsins are prototypical synaptic vesicle proteins that are regulated by Ca2+: Synaptotagmins directly via Ca2+ binding, and synapsins indirectly via phosphorylation by Ca(2+)-dependent protein kinases. Recently, a bewildering multiplicity in the expression of isoforms of these proteins has become apparent. Thus, mammalian brains express at least 8 isoforms of synaptotagmin and 4 isoforms of synapsin if variants arising by differential splicing are included. We have now used in situ hybridization to determine the relative localization of the expression of multiple isoforms of synapsins and synaptotagmins to complement previous studies on their distribution. Our results demonstrate that almost all brain regions co-express all four synapsins at similar levels, suggesting that they are not functionally alternative but complementary. The different isoforms of synaptotagmin exhibit two distinct expression patterns: synaptotagmins that are expressed in a highly differential manner (synaptotagmins I, II and VI), and synaptotagmins with a relatively even distribution of expression similar to synapsins (synaptotagmins III, IV and VII). Our data are consistent with a functional specialization of synaptic vesicle protein isoforms that could result in differential properties of the respective classes of neurons that express them.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1371-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Differential distributions of novel synaptotagmins: comparison to synapsins.
pubmed:affiliation
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't