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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-5-15
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pubmed:databankReference |
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pubmed:abstractText |
Uroguanylin, a member of the guanylin peptide family, is an endogenous activator of intestinal guanylate cyclase (GC-C). A cDNA encoding a precursor for human uroguanylin was cloned from a human colon cDNA library and sequenced. The precursor was 112 amino acids long and included a signal peptide at the N-terminus and the human uroguanylin sequence at the C-terminus. RNA blot analysis and the reverse transcription-polymerase chain reaction (RT-PCR) showed that human uroguanylin mRNA is expressed in the stomach and intestine. Uroguanylin, as well as guanylin, may be a potent physiological regulator of intestinal fluid and electrolyte transport.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrointestinal Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Sorting Signals,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/guanylin,
http://linkedlifedata.com/resource/pubmed/chemical/preproguanylin,
http://linkedlifedata.com/resource/pubmed/chemical/uroguanylin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
219
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
644-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8605041-Amino Acid Sequence,
pubmed-meshheading:8605041-Base Sequence,
pubmed-meshheading:8605041-Cloning, Molecular,
pubmed-meshheading:8605041-DNA, Complementary,
pubmed-meshheading:8605041-DNA Primers,
pubmed-meshheading:8605041-Gastrointestinal Hormones,
pubmed-meshheading:8605041-Gene Expression,
pubmed-meshheading:8605041-Gene Library,
pubmed-meshheading:8605041-Humans,
pubmed-meshheading:8605041-Molecular Sequence Data,
pubmed-meshheading:8605041-Natriuretic Peptides,
pubmed-meshheading:8605041-Oligonucleotides, Antisense,
pubmed-meshheading:8605041-Peptide Biosynthesis,
pubmed-meshheading:8605041-Peptides,
pubmed-meshheading:8605041-Polymerase Chain Reaction,
pubmed-meshheading:8605041-Protein Precursors,
pubmed-meshheading:8605041-Protein Sorting Signals,
pubmed-meshheading:8605041-RNA, Messenger,
pubmed-meshheading:8605041-Sequence Homology, Amino Acid
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pubmed:year |
1996
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pubmed:articleTitle |
Cloning and characterization of a cDNA encoding a precursor for human uroguanylin.
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pubmed:affiliation |
Third Department of Medicine, Miyazaki Medical College, Kiyotake, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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