Linked Life Data

8604687

Source:http://linkedlifedata.com/resource/pubmed/id/8604687

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-5-15
pubmed:abstractText
The clinical and morphologic distinction between small lymphocytic lymphoma (SLL)/ chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) is often challenging and has important prognostic and therapeutic implications. The authors investigated the usefulness of the marker CD23 in discriminating between these processes by flow cytometric immunophenotypic analysis. Consecutive samples of body fluids and hematopoietic tissue from patients with suspected B-cell lymphoproliferative disorders were studied using a panel of antibodies that included pan-B cell markers, CD5, FMC7, and CD23. Specimens from 38 patients with CD5-positive B-cell lymphoproliferative disorders consisting of a monomorphic population of small lymphoid cells were identified. Using standard flow cytometric and/or morphologic criteria, 28 patients were classified as having SLL/CLL and 10 were classified as having MCL. Neoplastic cells from all 28 patients (100%) with SLL/CLL demonstrated CD23 immunoreactivity, whereas neoplastic cells from none of the 10 patients (0%) with MCL demonstrated CD23 immunoreactivity (P < .0001). FMC7 immunoreactivity was observed in one of eight cases of SLL/CLL and in five of five cases of MCL (P = .0047). In conclusion, CD23 is a useful marker for the subclassification of CD5-positive B-cell lymphoproliferative disorders by flow cytometric analysis. FMC7 also may be a useful marker for subclassification.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9173
pubmed:author
pubmed:issnType
Print
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
451-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The utility of flow cytometric immunophenotypic analysis in the distinction of small lymphocytic lymphoma/chronic lymphocytic leukemia from mantle cell lymphoma.
pubmed:affiliation
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
pubmed:publicationType
Journal Article