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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-5-15
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pubmed:abstractText |
Mass spectrometry-based methods have been used to study post-transcriptional modification in the 1900-1974 nt segment of domain IV in 23S rRNA of Escherichia coli, a region which interacts with domain V in forming the three- dimensional structure of the peptidyl transferase center within the ribosome. A nucleoside constituent of M r 258 (U*)which occurs at position 1915, within the highly modified oligonucleotide sequence 1911-psiAACU*Apsi-1917, was characterized as 3-methylpseudouridine (m3psi). The assignment was confirmed by chemical synthesis of m3psi and comparison with the natural nucleoside by liquid chromatography-mass spectrometry. 3-Methylpseudouridine is previously unknown in nature and is the only known derivative of the common modified nucleoside pseudouridine thus far found in bacterial rRNA.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-11400439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-117844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-1225623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-1372517,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-1384701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-1587345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-1706062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-1706064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-1712937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-1883196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-2247610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-2415928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-2434656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-2470511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-3304135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-4299552,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-5438022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-6153795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-6163215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-629754,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-8422963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8604311-8559660
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
688-93
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1996
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pubmed:articleTitle |
Structural characterization of U*-1915 in domain IV from Escherichia coli 23S ribosomal RNA as 3-methylpseudouridine.
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pubmed:affiliation |
Department of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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