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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1996-5-16
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pubmed:abstractText |
Integrin-mediated extracellular matrix (ECM) attachment plays an important role in vitreous contraction of retinal pigment epithelial (RPE) cells. Disintegrins, a group of Arg-Gly-Asp (RGD)-containing peptides from viper venom, are potential anti-adhesion agents that interfere with integrin-ECM binding. This study was performed to determine whether disintegrins were effective in inhibiting RPE cell-induced matrix attachment in vitro and tractional retinal detachment in a rabbit model in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Crotalid Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Viper Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/arginyl-glycyl-aspartic acid,
http://linkedlifedata.com/resource/pubmed/chemical/echistatin,
http://linkedlifedata.com/resource/pubmed/chemical/flavoridin protein, Trimeresurus,
http://linkedlifedata.com/resource/pubmed/chemical/glycyl-arginyl-glycyl-aspartyl-serin...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
843-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8603869-Amino Acid Sequence,
pubmed-meshheading:8603869-Animals,
pubmed-meshheading:8603869-Antineoplastic Agents,
pubmed-meshheading:8603869-Cattle,
pubmed-meshheading:8603869-Cell Adhesion,
pubmed-meshheading:8603869-Cells, Cultured,
pubmed-meshheading:8603869-Crotalid Venoms,
pubmed-meshheading:8603869-Dose-Response Relationship, Drug,
pubmed-meshheading:8603869-Extracellular Matrix,
pubmed-meshheading:8603869-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:8603869-Integrins,
pubmed-meshheading:8603869-Molecular Sequence Data,
pubmed-meshheading:8603869-Oligopeptides,
pubmed-meshheading:8603869-Peptides,
pubmed-meshheading:8603869-Pigment Epithelium of Eye,
pubmed-meshheading:8603869-Platelet Aggregation Inhibitors,
pubmed-meshheading:8603869-Rabbits,
pubmed-meshheading:8603869-Retinal Detachment,
pubmed-meshheading:8603869-Viper Venoms,
pubmed-meshheading:8603869-Vitreoretinopathy, Proliferative,
pubmed-meshheading:8603869-Vitreous Body
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pubmed:year |
1996
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pubmed:articleTitle |
Inhibition of retinal pigment epithelial cell-induced tractional retinal detachment by disintegrins, a group of Arg-Gly-Asp-containing peptides from viper venom.
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pubmed:affiliation |
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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